Yura Noriko, Kira Hiromasa, Chigusa Yoshitsugu, Kawatou Masahide, Kubo Nozomi, Komatsu Maya, Takakura Masahito, Mogami Haruta, Minatoya Kenji, Mandai Masaki
Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Department of Cardiac Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Nagoya J Med Sci. 2025 May;87(2):374-379. doi: 10.18999/nagjms.87.2.374.
Innominate artery aneurysms are rare, accounting for only 0.26% of all aneurysms. Although usually asymptomatic, they carry a significant risk of rupture, which can be fatal, making timely diagnosis and treatment essential. There is limited literature on the management of innominate artery aneurysms during pregnancy, and no established treatment guidelines exist. In this case, a 42-year-old multigravida woman was diagnosed with an innominate artery aneurysm four years prior to pregnancy. Genetic panel testing ruled out inherited connective tissue disorders, including Marfan syndrome. The aneurysm measured 24 × 36 mm and possessed a saccular configuration. At 23 weeks of gestation, due to the high risk of rupture, the patient underwent successful endovascular stent grafting without complications. Later, the patient developed preeclampsia and fetal growth restriction, necessitating an emergency cesarean section at 33 weeks. A female infant was delivered, and both mother and neonate were discharged without further complications. Open surgical intervention with cardiopulmonary bypass is the standard therapeutic approach for innominate artery aneurysms. However, maternal and fetal mortality rates associated with cardiopulmonary bypass during pregnancy are high. This case suggests that although innominate artery aneurysms during pregnancy are exceedingly rare, endovascular repair with stent grafting may be a viable treatment option to avoid the serious maternal and fetal risks associated with aneurysm rupture or open surgical repair.
无名动脉动脉瘤较为罕见,仅占所有动脉瘤的0.26%。尽管通常无症状,但它们具有很高的破裂风险,可能会致命,因此及时诊断和治疗至关重要。关于孕期无名动脉动脉瘤的治疗,相关文献有限,且尚无既定的治疗指南。在本病例中,一名42岁的经产妇在怀孕前四年被诊断出患有无名动脉动脉瘤。基因检测排除了包括马凡综合征在内的遗传性结缔组织疾病。动脉瘤大小为24×36mm,呈囊状。妊娠23周时,由于破裂风险高,患者成功接受了血管内支架植入术,且未出现并发症。后来,患者出现子痫前期和胎儿生长受限,因此在33周时进行了紧急剖宫产。一名女婴出生,母婴均顺利出院,无进一步并发症。体外循环下的开放手术干预是无名动脉动脉瘤的标准治疗方法。然而,孕期体外循环相关的母婴死亡率很高。本病例表明,尽管孕期无名动脉动脉瘤极为罕见,但血管内支架植入修复术可能是一种可行的治疗选择,可避免与动脉瘤破裂或开放手术修复相关的严重母婴风险。