Al-Salmi Nasser, Muliira Joshua K, Lazarus Eilean Rathinasamy
Department of Adult Health and Critical Care, College of Nursing, Sultan Qaboos University, Muscat, Oman.
Patient Prefer Adherence. 2025 Jul 31;19:2263-2281. doi: 10.2147/PPA.S526844. eCollection 2025.
Medication adherence is a critical factor in the management of Type 2 Diabetes (T2D) and plays a vital role in slowing disease progression, preventing complications and improving health outcomes. This study fills this gap by systematically integrating findings from qualitative studies to provide a comprehensive understanding of the multilevel determinants of adherence unique to the MENA sociocultural context.
A metasynthesis was conducted using a thematic synthesis approach, incorporating data from nine qualitative studies. The search was limited to research articles published in English between 2014 and 2024.
The metasynthesis identified four key themes: (1) personal factors and perceptions related to the disease and medications are fundamental to adherence, (2) healthcare provider attitudes and practices can improve adherence to medications, (3) the healthcare system is a key factor for optimal adherence, and (4) sociocultural, alternative medicine, and religious practices affect adherence in the MENA region.
Medication adherence among adults with T2D in the MENA region is influenced by factors related to the individual patients, healthcare providers, healthcare system, and sociocultural practices. There is a need for more qualitative studies to address existing knowledge gaps about the agency of the above factors in regard to initiation and control of actions that lead to medication adherence.
药物依从性是2型糖尿病（T2D）管理中的关键因素，在减缓疾病进展、预防并发症和改善健康结局方面发挥着至关重要的作用。本研究通过系统整合定性研究的结果，填补了这一空白，以全面了解中东和北非社会文化背景下特有的依从性多层次决定因素。
采用主题综合法进行元综合分析，纳入了9项定性研究的数据。检索限于2014年至2024年期间发表的英文研究文章。
元综合分析确定了四个关键主题：（1）与疾病和药物相关的个人因素和认知是依从性的基础；（2）医疗服务提供者的态度和做法可提高药物依从性；（3）医疗系统是实现最佳依从性的关键因素；（4）社会文化、替代医学和宗教习俗影响中东和北非地区的依从性。
中东和北非地区成年T2D患者的药物依从性受个体患者、医疗服务提供者、医疗系统以及社会文化习俗等相关因素的影响。需要开展更多定性研究，以填补关于上述因素在导致药物依从性的行动启动和控制方面作用的现有知识空白。
