Chen Xiaoqin, Li Zhitong, Liu Tao, Li Xingyu, Li Xuhui, Duan Ruixue, Liu Shiwei
Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Tongji Shanxi Hospital, Shanxi Academy of Medical Sciences, Taiyuan, Shanxi, China.
Department of Endocrinology, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Tongji Shanxi Hospital, Shanxi Academy of Medical Sciences, Taiyuan, Shanxi, China.
Int J Endocrinol. 2025 Jul 29;2025:2259853. doi: 10.1155/ije/2259853. eCollection 2025.
The cardiometabolic index (CMI) serves as a comprehensive indicator of metabolic risk. Recent findings indicate a potential association between CMI and the likelihood of diabetes onset. The objective of this research is to explore the correlation between initial CMI values and the occurrence of newly diagnosed diabetes mellitus in individuals aged 45 years and above in China. In this research, data were sourced from the China Health and Retirement Longitudinal Study (CHARLS). To evaluate the association between baseline CMI and the incidence of newly diagnosed diabetes, multivariate logistic regression models were employed, with adjustments made for various potential confounding factors. Additionally, stratified analyses evaluated subgroup variations, and mediation analysis explored pathways through which CMI influences diabetes risk. A cohort of 4,944 participants was followed, with 786 diagnosed with new-onset diabetes. The occurrence of diabetes escalated with increasing CMI quartiles, with Q4 showing a 141% increased risk (OR 2.41, 95% CI, 1.94-3.02) in unadjusted models. This association remained significant after adjustment. Stratified analyses found that dyslipidemia modified the CMI-diabetes association. CMI, age, BMI, HbA1c, and hypertension were identified as independent predictors of new-onset diabetes. Mediation analysis revealed that HbA1c mediated 9.70% of the CMI-diabetes relationship. In summary, our research establishes a connection between increased levels of CMI and the onset of diabetes, suggesting its potential as a predictive tool. The findings highlight CMI's role in assessing diabetes risk and call for targeted interventions. Future research should validate these associations and explore underlying mechanisms for better prevention strategies.
心脏代谢指数（CMI）是代谢风险的综合指标。最近的研究结果表明CMI与糖尿病发病可能性之间存在潜在关联。本研究的目的是探讨中国45岁及以上人群初始CMI值与新诊断糖尿病发生之间的相关性。在本研究中，数据来源于中国健康与养老追踪调查（CHARLS）。为了评估基线CMI与新诊断糖尿病发病率之间的关联，采用了多变量逻辑回归模型，并对各种潜在混杂因素进行了调整。此外，分层分析评估了亚组差异，中介分析探讨了CMI影响糖尿病风险的途径。对4944名参与者进行了随访，其中786人被诊断为新发糖尿病。糖尿病的发生率随着CMI四分位数的增加而上升，在未调整模型中，Q4显示风险增加141%（OR 2.41，95%CI，1.94 - 3.02）。调整后这种关联仍然显著。分层分析发现血脂异常改变了CMI与糖尿病之间的关联。CMI、年龄、BMI、糖化血红蛋白（HbA1c）和高血压被确定为新发糖尿病的独立预测因素。中介分析显示，HbA1c介导了CMI与糖尿病关系的9.70%。总之，我们的研究建立了CMI水平升高与糖尿病发病之间的联系，表明其作为预测工具的潜力。研究结果突出了CMI在评估糖尿病风险中的作用，并呼吁采取有针对性的干预措施。未来的研究应验证这些关联，并探索潜在机制以制定更好的预防策略。
