ERCC1-XPF核酸酶在处理非B型DNA结构中的多方面作用

Multi-Faceted Roles of ERCC1-XPF Nuclease in Processing Non-B DNA Structures.

作者信息

Li Tonia T, Vasquez Karen M

机构信息

Division of Pharmacology and Toxicology, Dell Pediatric Research Institute, College of Pharmacy, The University of Texas at Austin, 1400 Barbara Jordan Boulevard, Austin, TX 78723, USA.

出版信息

DNA (Basel). 2022 Dec;2(4):231-247. doi: 10.3390/dna2040017. Epub 2022 Oct 11.

DOI:10.3390/dna2040017

PMID:40766048

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12323751/

Abstract

Genetic instability can result from increases in DNA damage and/or alterations in DNA repair proteins and can contribute to disease development. Both exogenous and endogenous sources of DNA damage and/or alterations in DNA structure (e.g., non-B DNA) can impact genome stability. Multiple repair mechanisms exist to counteract DNA damage. One key DNA repair protein complex is ERCC1-XPF, a structure-specific endonuclease that participates in a variety of DNA repair processes. ERCC1-XPF is involved in nucleotide excision repair (NER), repair of DNA interstrand crosslinks (ICLs), and DNA double-strand break (DSB) repair via homologous recombination. In addition, ERCC1-XPF contributes to the processing of various alternative (i.e., non-B) DNA structures. This review will focus on the processing of alternative DNA structures by ERCC1-XPF.

摘要

基因不稳定可由DNA损伤增加和/或DNA修复蛋白改变引起，并可能促进疾病发展。DNA损伤的外源性和内源性来源以及/或DNA结构改变（例如，非B型DNA）均可影响基因组稳定性。存在多种修复机制来对抗DNA损伤。一种关键的DNA修复蛋白复合物是ERCC1-XPF，它是一种结构特异性核酸内切酶，参与多种DNA修复过程。ERCC1-XPF参与核苷酸切除修复（NER）、DNA链间交联（ICL）修复以及通过同源重组进行的DNA双链断裂（DSB）修复。此外，ERCC1-XPF有助于处理各种替代性（即非B型）DNA结构。本综述将聚焦于ERCC1-XPF对替代性DNA结构的处理。