修复蛋白对替代性DNA结构进行诱变处理的不同机制。
Distinct mechanisms of mutagenic processing of alternative DNA structures by repair proteins.
作者信息
McKinney Jennifer A, Wang Guliang, Vasquez Karen M
机构信息
Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, Austin, TX, USA.
出版信息
Mol Cell Oncol. 2020 Apr 2;7(3):1743807. doi: 10.1080/23723556.2020.1743807. eCollection 2020.
Repetitive sequences can form a variety of alternative DNA structures (non-B DNA) that can modulate transcription, replication, and repair. However, non-B DNA-forming sequences can also stimulate mutagenesis, and are enriched at mutation hotspots in human cancer genomes. Interestingly, different types of non-B DNA stimulate mutagenesis via distinct repair processing mechanisms.
重复序列可形成多种可调节转录、复制和修复的替代性DNA结构（非B型DNA）。然而，形成非B型DNA的序列也可刺激诱变作用，并且在人类癌症基因组的突变热点处富集。有趣的是，不同类型的非B型DNA通过不同的修复加工机制刺激诱变作用。
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