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本文引用的文献

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Clinical Trials for Pediatric Extracorporeal Membrane Oxygenation: The Time Is Now!儿童体外膜肺氧合的临床试验:时机已到!
Pediatr Crit Care Med. 2025 Jan 1;26(1):e118-e121. doi: 10.1097/PCC.0000000000003660. Epub 2024 Dec 4.
2
Definitions of adverse events associated with extracorporeal membrane oxygenation in children: results of an international Delphi process from the ECMO-CENTRAL ARC.与儿童体外膜肺氧合相关的不良事件定义:来自 ECMO-CENTRAL ARC 的国际 Delphi 过程的结果。
Lancet Child Adolesc Health. 2024 Oct;8(10):773-780. doi: 10.1016/S2352-4642(24)00132-9.
3
Early endothelial injury in cardiogenic shock patients on venoarterial ECMO.接受静脉-动脉体外膜肺氧合治疗的心源性休克患者的早期内皮损伤
Intensive Care Med. 2024 Nov;50(11):1929-1930. doi: 10.1007/s00134-024-07642-x. Epub 2024 Sep 17.
4
Improving oxygenation in severe ARDS treated with VV-ECMO: comparative efficacy of moderate hypothermia and landiolol in a swine ARDS model.体外膜肺氧合(VV-ECMO)治疗重症急性呼吸窘迫综合征(ARDS)时改善氧合的效果:猪ARDS模型中中度低温与兰地洛尔的疗效比较
Intensive Care Med Exp. 2024 Aug 27;12(1):74. doi: 10.1186/s40635-024-00655-2.
5
Comprehensive Characterization of Surface-Bound Proteins and Measurement of Fibrin Fiber Thickness on Extracorporeal Membrane Oxygenation Circuits Collected From Patients.从患者体外膜肺氧合回路中收集的表面结合蛋白的综合特征描述及纤维蛋白纤维厚度的测量。
Pediatr Crit Care Med. 2024 Nov 1;25(11):1017-1025. doi: 10.1097/PCC.0000000000003591. Epub 2024 Aug 13.
6
Critical hematological parameters in bleeding during extracorporeal membrane oxygenation support.体外膜肺氧合支持期间出血的关键血液学参数
J Artif Organs. 2025 Mar;28(1):25-29. doi: 10.1007/s10047-024-01466-8. Epub 2024 Aug 12.
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Temporal changes in markers of coagulation and fibrinolysis in adults during extracorporeal membrane oxygenation.体外膜肺氧合期间成人凝血和纤溶标志物的时间变化。
Perfusion. 2025 May;40(4):984-992. doi: 10.1177/02676591241267218. Epub 2024 Jul 25.
8
Priorities for Clinical Research in Pediatric Extracorporeal Membrane Oxygenation Anticoagulation From the Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference.儿科体外膜肺氧合抗凝的临床研究重点:来自儿科体外膜肺氧合抗凝协作共识会议。
Pediatr Crit Care Med. 2024 Jul 1;25(7 Suppl 1):e78-e89. doi: 10.1097/PCC.0000000000003488. Epub 2024 Jul 3.
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体外膜肺氧合诱导的凝血病:研究与临床实践的战略举措(美国国立心肺血液研究所研讨会报告)

ECMO-induced coagulopathy: strategic initiatives for research and clinical practice (a workshop report of the NHLBI).

作者信息

Levy Jerrold H, Alexander Peta M A, Wolberg Alisa S, McCarty Owen J T, Pusateri Anthony E, Bartz Raquel R, Bergmeier Wolfgang, Cohen Mitchell J, Connors Jean M, Morrissey James H, Neal Matthew D, Tracy Elisabeth T, McCrae Keith, Sullenger Bruce A

机构信息

Department of Anesthesiology, Critical Care, and Surgery (Cardiothoracic), Duke University School of Medicine, Durham, NC.

Department of Cardiology, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA.

出版信息

Blood Vessel Thromb Hemost. 2025 Feb 25;2(2):100064. doi: 10.1016/j.bvth.2025.100064. eCollection 2025 May.

DOI:10.1016/j.bvth.2025.100064
PMID:
40766281
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12320426/
Abstract

In May 2024, the Division of Blood Diseases and Resources of the National Heart, Lung, and Blood Institute (NHLBI) hosted a hybrid workshop on "Extracorporeal membrane oxygenation (ECMO)-induced coagulopathy: strategic initiatives for research and clinical practice." The event brought together clinicians, scientists, bioengineers, and policymakers to address the challenges of ECMO-associated coagulopathy and explore novel therapeutic approaches. Through expert presentations and collaborative discussions, the workshop focused on innovative anticoagulation strategies, precision medicine, and advanced diagnostics to enhance patient care. The discussions also identified critical research gaps and opportunities for future interdisciplinary collaboration. This summary reviews the current state of knowledge and outlines future research directions for improving ECMO-induced coagulopathy management.

摘要

2024年5月,美国国立心肺血液研究所(NHLBI)血液疾病与资源司主办了一场关于“体外膜肺氧合(ECMO)诱导的凝血病:研究与临床实践的战略举措”的混合研讨会。该活动汇聚了临床医生、科学家、生物工程师和政策制定者,以应对ECMO相关凝血病的挑战,并探索新的治疗方法。通过专家演讲和合作讨论,研讨会聚焦于创新的抗凝策略、精准医学和先进诊断,以改善患者护理。讨论还确定了关键的研究差距以及未来跨学科合作的机会。本总结回顾了当前的知识状况,并概述了改善ECMO诱导的凝血病管理的未来研究方向。