Rendine Marco, Marino Mirko, Martini Daniela, Riso Patrizia, Møller Peter, Del Bo' Cristian
Division of Human Nutrition, Department of Food, Environmental and Nutritional Sciences (DeFENS), Università Degli Studi Di Milano, Milano, Italy.
Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
Curr Obes Rep. 2025 Aug 6;14(1):64. doi: 10.1007/s13679-025-00656-6.
This systematic review aims to elucidate the effects of (poly)phenols (PPs) on mature 3T3-L1 adipocytes via the regulation of lipid and glucose metabolism.
PPs can modulate glucose uptake, reduce intracellular lipid content and enhance lipolytic activity in mature 3T3-L1 adipocytes. These effects are mediated through changes at both gene expression level (e.g. Ppara and Sirt1) and protein level (e.g. activation of AMPK and adiponectin levels). However, there is no consensus on the concentrations at which PPs exert their anti-lipogenic activity, and it remains unclear whether different PPs activate distinct molecular pathways. PPs are a diverse group of plant-derived secondary metabolites with recognized anti-obesogenic potential. While their inhibitory effects on adipogenesis are well established, their role in modulating lipid metabolism in fully differentiated adipocytes remains less well understood. Emerging evidence from studies on mature 3T3-L1 adipocytes indicates that PPs can influence key metabolic processes, including lipid storage and mobilization. These findings highlight the potential of PPs as modulators of adipose tissue metabolism, while also emphasizing the need for translational research to clarify their mechanisms of action and therapeutic efficacy in vivo.
本系统综述旨在阐明（多）酚类物质（PPs）通过调节脂质和葡萄糖代谢对成熟3T3-L1脂肪细胞的影响。
PPs可调节成熟3T3-L1脂肪细胞的葡萄糖摄取，降低细胞内脂质含量并增强脂解活性。这些作用是通过基因表达水平（如Ppara和Sirt1）和蛋白质水平（如AMPK激活和脂联素水平）的变化介导的。然而，关于PPs发挥抗脂肪生成活性的浓度尚无共识，并且不同的PPs是否激活不同的分子途径仍不清楚。PPs是一类多样的植物源次生代谢产物，具有公认的抗肥胖潜力。虽然它们对脂肪生成的抑制作用已得到充分证实，但其在调节完全分化的脂肪细胞脂质代谢中的作用仍了解较少。对成熟3T3-L1脂肪细胞研究的新证据表明，PPs可影响关键的代谢过程，包括脂质储存和动员。这些发现突出了PPs作为脂肪组织代谢调节剂的潜力，同时也强调了开展转化研究以阐明其体内作用机制和治疗效果的必要性。
