Mortazavi Hamed, Taheri Anita, Alehossein Sara, Hashemi Mehdi
Department of Oral Medicine, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Saudi Dent J. 2025 Aug 6;37(7-9):36. doi: 10.1007/s44445-025-00043-w.
Metastasis to the temporomandibular joint is an uncommon clinical entity that often mimics benign temporomandibular disorders, leading to diagnostic challenges. This systematic review aimed to consolidate the existing literature on temporomandibular joint metastasis to delineate its clinical and demographic characteristics, diagnostic pitfalls, and treatment approaches.
A comprehensive search was conducted across PubMed/MEDLINE, Scopus, and Embase electronic databases. Two independent reviewers screened the titles, abstracts, and full texts of 3,659 articles, ultimately selecting 47 articles encompassing 55 reported cases.
The analysis revealed a mean patient age of 61.8 ± 13.99 years, with a slight female predominance. Lung and breast cancers were the most common primary sites, with adenocarcinoma being the predominant histopathological type. Clinically, pain, swelling, and restricted mouth opening were the most frequently observed symptoms, although a subset of patients presented with atypical features. Notably, in 49% of cases, TMJ metastasis was detected prior to the diagnosis of the primary malignancy. Multimodal treatment, incorporating combinations of chemotherapy, radiotherapy, and surgery, was the most common therapeutic approach.
颞下颌关节转移是一种罕见的临床情况，常类似于良性颞下颌关节疾病，导致诊断困难。本系统评价旨在整合现有的关于颞下颌关节转移的文献，以描述其临床和人口统计学特征、诊断陷阱及治疗方法。
在PubMed/MEDLINE、Scopus和Embase电子数据库中进行了全面检索。两名独立的评审员筛选了3659篇文章的标题、摘要和全文，最终选择了47篇文章，涵盖55例报告病例。
分析显示患者平均年龄为61.8±13.99岁，女性略占优势。肺癌和乳腺癌是最常见的原发部位，腺癌是主要的组织病理学类型。临床上，疼痛、肿胀和张口受限是最常观察到的症状，尽管有一部分患者表现出非典型特征。值得注意的是，在49%的病例中，颞下颌关节转移在原发性恶性肿瘤诊断之前就被检测到。多模式治疗，包括化疗、放疗和手术的联合应用，是最常见的治疗方法。
