Abaza Tasneem, Mohamed Eman E, Zaky Mohamed Y
Biotechnology Program, Institute of Basic and Applied Sciences (BAS), Egypt-Japan University of Science and Technology (E-JUST), New Borg El-Arab City, 21934, Alexandria, Egypt.
Molecular Physiology Division, Department of Zoology, Faculty of Science, Beni-Suef University, P.O. Box 62511, Beni-Suef, Egypt.
Med Oncol. 2025 Aug 6;42(9):409. doi: 10.1007/s12032-025-02939-3.
Cancer immunotherapy and nucleic acid therapy have demonstrated significant potential in reshaping cancer treatment paradigms. The combination of these therapeutic approaches offers promising prospects for enhancing systemic anti-tumor effects while minimizing adverse reactions commonly associated with traditional treatments. However, the clinical efficacy of these innovative therapies is often hindered by several delivery-related challenges. These include issues like degradation of therapeutic molecules, limited cellular uptake, the essential requirement for nuclear entry, and risks of off-target toxicity that can negatively impact patient safety. In this challenging landscape, nanoparticle delivery systems, particularly lipid nanoparticles (LNPs), have emerged as a groundbreaking solution to overcome these obstacles. LNPs facilitate the safe and efficient delivery of nucleic acid therapy directly to immune cells, enhancing their bioavailability and therapeutic impact. This review article examines the evolving role of LNPs in the landscape of cancer immunotherapy. Recent advancements in LNP-based nucleic acid delivery illustrate their potential to revolutionize the field by enabling precise modulation of gene expression and immune responses, paving the way for improved cancer treatment outcomes and providing a more effective arsenal against this complex disease.
癌症免疫疗法和核酸疗法在重塑癌症治疗模式方面已展现出巨大潜力。这些治疗方法的联合应用为增强全身抗肿瘤效果提供了广阔前景，同时将传统治疗常见的不良反应降至最低。然而，这些创新疗法的临床疗效常常受到一些与递送相关的挑战的阻碍。这些挑战包括治疗分子降解、细胞摄取有限、进入细胞核的必要性以及脱靶毒性风险等问题，这些都可能对患者安全产生负面影响。在这一充满挑战的局面下，纳米颗粒递送系统，尤其是脂质纳米颗粒（LNPs），已成为克服这些障碍的开创性解决方案。LNPs有助于将核酸疗法安全、高效地直接递送至免疫细胞，提高其生物利用度和治疗效果。这篇综述文章探讨了LNPs在癌症免疫治疗领域不断演变的作用。基于LNP的核酸递送的最新进展表明，它们有潜力通过实现对基因表达和免疫反应的精确调控来彻底改变该领域，为改善癌症治疗效果铺平道路，并为对抗这种复杂疾病提供更有效的手段。
