• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Combination therapy of an At-labeled RGD peptide and immune checkpoint blockade to enhance antitumor efficacy.

作者信息

Echigo Hiroaki, Munekane Masayuki, Fuchigami Takeshi, Washiyama Kohshin, Nakamura Takashi, Furukawa Atsushi, Chen Zhuoqing, Mishiro Kenji, Wakabayashi Hiroshi, Takahashi Kazuhiro, Kinuya Seigo, Ogawa Kazuma

机构信息

Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Ishikawa, Japan.

Advanced Clinical Research Center, Fukushima Global Medical Science Center, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960-1295, Japan.

出版信息

Eur J Nucl Med Mol Imaging. 2025 Aug 6. doi: 10.1007/s00259-025-07498-3.

DOI:10.1007/s00259-025-07498-3
PMID:40768094
Abstract
摘要

相似文献

1
Combination therapy of an At-labeled RGD peptide and immune checkpoint blockade to enhance antitumor efficacy.一种放射性核素标记的RGD肽与免疫检查点阻断的联合疗法以增强抗肿瘤疗效。
Eur J Nucl Med Mol Imaging. 2025 Aug 6. doi: 10.1007/s00259-025-07498-3.
2
Combination of low-intensity pulsed ultrasound irradiating immune organs with immune checkpoint blockade augments systemic anti-tumor immunity on low tumor burden 4T-1 breast cancer.低强度脉冲超声照射免疫器官与免疫检查点阻断相结合可增强低肿瘤负荷4T-1乳腺癌的全身抗肿瘤免疫力。
Cancer Immunol Immunother. 2025 Aug 6;74(9):281. doi: 10.1007/s00262-025-04137-6.
3
Synergistic Antitumor Effect on Bladder Cancer by Rational Combination of Programmed Cell Death 1 Blockade and CRISPR-Cas9-Mediated Long Non-Coding RNA Urothelial Carcinoma Associated 1 Knockout.程序性细胞死亡蛋白 1 阻断与 CRISPR-Cas9 介导的长链非编码 RNA 尿路上皮癌相关 1 敲除的合理联合对膀胱癌的协同抗肿瘤作用。
Hum Gene Ther. 2018 Dec;29(12):1352-1363. doi: 10.1089/hum.2018.048. Epub 2018 Nov 19.
4
Antitumor efficacy and potential mechanism of FAP-targeted radioligand therapy combined with immune checkpoint blockade.靶向 FAP 的放射性配体治疗联合免疫检查点阻断的抗肿瘤疗效及潜在机制。
Signal Transduct Target Ther. 2024 Jun 3;9(1):142. doi: 10.1038/s41392-024-01853-w.
5
rhIL-7-hyFc and hIL-2/TCB2c combination promotes an immune-stimulatory tumor microenvironment that improves antitumor efficacy of checkpoint inhibitors.重组人白细胞介素-7-杂交Fc片段与人白细胞介素-2/TCB2c组合可促进免疫刺激肿瘤微环境，提高检查点抑制剂的抗肿瘤疗效。
J Immunother Cancer. 2024 Mar 12;12(3):e008001. doi: 10.1136/jitc-2023-008001.
6
Targeting Innate Immune Checkpoint TREX1 Is a Safe and Effective Immunotherapeutic Strategy in Cancer.靶向天然免疫检查点TREX1是一种安全有效的癌症免疫治疗策略。
Cancer Res. 2025 Aug 1;85(15):2858-2875. doi: 10.1158/0008-5472.CAN-24-2747.
7
Systemic treatments for metastatic cutaneous melanoma.转移性皮肤黑色素瘤的全身治疗
Cochrane Database Syst Rev. 2018 Feb 6;2(2):CD011123. doi: 10.1002/14651858.CD011123.pub2.
8
Elucidating the role of N-myristoylation in the excessive membrane localization of PD-L1 in hypoxic cancers and developing a novel NMT1 inhibitor for combination with immune checkpoint blockade therapy.阐明N-肉豆蔻酰化在缺氧癌症中程序性死亡受体配体1（PD-L1）过度膜定位中的作用，并开发一种新型N-肉豆蔻酰转移酶1（NMT1）抑制剂，用于与免疫检查点阻断疗法联合使用。
J Exp Clin Cancer Res. 2025 Jul 2;44(1):181. doi: 10.1186/s13046-025-03438-z.
9
Engineering a Radiohybrid PSMA Ligand with an Albumin-Binding Moiety and Pharmacokinetic Modulation via an Albumin-Binding Competitor for Radiotheranostics.通过白蛋白结合竞争剂设计一种具有白蛋白结合部分并进行药代动力学调控的放射性杂交PSMA配体用于放射治疗诊断。
Molecules. 2025 Jun 29;30(13):2804. doi: 10.3390/molecules30132804.
10
Antigen-loaded Monocyte Administration and Flt3 Ligand Augment the Antitumor Efficacy of Immune Checkpoint Blockade in a Murine Melanoma Model.抗原负载单核细胞给药和 Flt3 配体增强免疫检查点阻断在小鼠黑色素瘤模型中的抗肿瘤疗效。
J Immunother. 2023;46(9):333-340. doi: 10.1097/CJI.0000000000000487. Epub 2023 Sep 20.

本文引用的文献

1
Development of Radiolabeled Probes with Improved Imaging Contrast by Releasing Urinary Excretable Radiolabeled Compounds from Thermosensitive Liposomes in the Blood.通过在血液中从热敏脂质体中释放可经尿液排泄的放射性标记化合物来开发具有改善的成像对比度的放射性标记探针。
Mol Pharm. 2024 Nov 4;21(11):5728-5735. doi: 10.1021/acs.molpharmaceut.4c00732. Epub 2024 Oct 24.
2
Intratumoral radiation dose heterogeneity augments antitumor immunity in mice and primes responses to checkpoint blockade.肿瘤内放射剂量异质性增强了小鼠的抗肿瘤免疫，并为检查点阻断治疗做出反应做好准备。
Sci Transl Med. 2024 Sep 18;16(765):eadk0642. doi: 10.1126/scitranslmed.adk0642.
3
Radiotherapy, immunity, and immune checkpoint inhibitors.
放疗、免疫与免疫检查点抑制剂。
Lancet Oncol. 2024 Aug;25(8):e352-e362. doi: 10.1016/S1470-2045(24)00075-5.
4
Near-infrared photoimmunotherapy targeting PD-L1: Improved efficacy by preconditioning the tumor microenvironment.近红外光免疫治疗靶向 PD-L1：通过预处理肿瘤微环境提高疗效。
Cancer Sci. 2024 Jul;115(7):2396-2409. doi: 10.1111/cas.16195. Epub 2024 Apr 26.
5
Optimizing the pharmacokinetics of an At-labeled RGD peptide with an albumin-binding moiety via the administration of an albumin-binding inhibitor.通过给予白蛋白结合抑制剂来优化带有白蛋白结合结构域的放射性标记 RGD 肽的药代动力学。
Eur J Nucl Med Mol Imaging. 2024 Jul;51(9):2663-2671. doi: 10.1007/s00259-024-06695-w. Epub 2024 Apr 4.
6
Recent advances in the development of Ac- and At-labeled radioligands for radiotheranostics.用于放射治疗诊断的锕和砹标记放射性配体开发的最新进展。
Anal Sci. 2024 May;40(5):803-826. doi: 10.1007/s44211-024-00514-w. Epub 2024 Apr 2.
7
E3MPH16: An efficient endosomolytic peptide for intracellular protein delivery.E3MPH16：一种高效的内体溶酶体肽，用于细胞内蛋白质递药。
J Control Release. 2024 Mar;367:877-891. doi: 10.1016/j.jconrel.2024.01.067. Epub 2024 Feb 20.
8
Development of probes for radiotheranostics with albumin binding moiety to increase the therapeutic effects of astatine-211 (At).开发具有白蛋白结合部分的放射性治疗探针，以提高放射性核素 211 砹（At）的治疗效果。
Eur J Nucl Med Mol Imaging. 2024 Jan;51(2):412-421. doi: 10.1007/s00259-023-06457-0. Epub 2023 Oct 11.
9
Effective Treatment of SSTR2-Positive Small Cell Lung Cancer Using At-Containing Targeted α-Particle Therapy Agent Which Promotes Endogenous Antitumor Immune Response.使用含有放射性 At 的靶向 α 粒子治疗剂有效治疗 SSTR2 阳性小细胞肺癌，该治疗剂可促进内源性抗肿瘤免疫反应。
Mol Pharm. 2023 Nov 6;20(11):5543-5553. doi: 10.1021/acs.molpharmaceut.3c00427. Epub 2023 Oct 3.
10
Astatine-211-labeled aza-vesamicol derivatives as sigma receptor ligands for targeted alpha therapy.砹-211标记的氮杂-维司那定衍生物作为用于靶向α治疗的σ受体配体
Nucl Med Biol. 2023 Jul-Aug;122-123:108369. doi: 10.1016/j.nucmedbio.2023.108369. Epub 2023 Jul 22.