大鼠长期摄入磷化氢熏蒸饲料的营养和毒理学效应。

Nutritional and toxicological effects of long-term ingestion of phosphine-fumigated diet by the rat.

作者信息

Cabrol Telle A M, de Saint Blanquat G, Derache R, Hollande E, Periquet B, Thouvenot J P

出版信息

Food Chem Toxicol. 1985 Nov;23(11):1001-9. doi: 10.1016/0278-6915(85)90251-0.

Abstract

The fumigation of stored foodstuffs with phosphine (PH3) is likely to become widely used in the future because of its technological efficiency and the rapid desorption of the fumigant. In a long-term feeding study of a phosphine-fumigated diet, rats were monitored for weight gain, food intake, plasma chemistry, haematology and urinary changes. Histopathological studies, including organ-weight determinations, were carried out after treatment of the rats for 1 and 2 yr. The results show that ingestion of a phosphine-fumigated diet by the rat for 2 yr does not cause any marked modification of growth, food intake, nitrogen balance, body composition, functional behaviour or the incidence or type of tumours.

摘要

由于磷化氢（PH₃）熏蒸储存食品具有技术效率高和熏蒸剂快速解吸的特点，未来可能会得到广泛应用。在一项关于磷化氢熏蒸饮食的长期喂养研究中，对大鼠的体重增加、食物摄入量、血浆化学、血液学和尿液变化进行了监测。在对大鼠进行1年和2年的治疗后，进行了组织病理学研究，包括器官重量测定。结果表明，大鼠摄入磷化氢熏蒸饮食2年不会导致生长、食物摄入量、氮平衡、身体组成、功能行为或肿瘤的发生率或类型发生任何显著改变。