Chung Sun Nou, Hurr Riley, Chen Hao-Wen, Kao Tzu-Ning, Lin Mong-Wei, Yang Chi-Fu Jeffrey
School of Medicine, National Taiwan University, Taipei City, Taiwan.
Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.
J Chest Surg. 2025 Sep 5;58(5):175-184. doi: 10.5090/jcs.25.017. Epub 2025 Aug 7.
Low-dose computed tomography (LDCT) screening is widely recognized as an effective tool for the early detection of lung cancer. However, its efficacy among individuals without a history of smoking continues to attract interest. Currently, nearly all lung cancer screening guidelines provide recommendations exclusively for individuals who currently smoke or have a history of smoking. Emerging research indicates that LDCT screening may also benefit individuals who have never smoked but are genetically predisposed to lung cancer or have been exposed to certain environmental risk factors. This underscores the need to consider expanding LDCT screening eligibility criteria to include carefully selected never-smokers at high risk, potentially preventing lung cancer-related deaths.
低剂量计算机断层扫描（LDCT）筛查被广泛认为是早期发现肺癌的有效工具。然而，其在无吸烟史个体中的有效性仍备受关注。目前，几乎所有肺癌筛查指南仅针对目前吸烟或有吸烟史的个体提供建议。新出现的研究表明，LDCT筛查可能也有益于从未吸烟但有肺癌遗传易感性或接触过某些环境风险因素的个体。这凸显了考虑扩大LDCT筛查资格标准以纳入精心挑选的高危非吸烟者的必要性，这有可能预防与肺癌相关的死亡。
