Pereira Ana Faria, Marques-Couto Pedro, Teixeira-Martins Rita, Rocha-Sousa Amândio, Alves-Faria Pedro, Araújo Joana R
Department of Ophthalmology, Unidade Local de Saúde São João, Alameda Prof. Hernâni Monteiro, 4200-319, Porto, Portugal.
Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.
Sci Rep. 2025 Aug 6;15(1):28796. doi: 10.1038/s41598-025-12905-8.
To assess intraocular pressure (IOP) changes and the development of ocular hypertension (OH) following pars plana vitrectomy (PPV), evaluating short- and long-term outcomes and risk factors. This is a retrospective study of 216 patients (432 eyes) who underwent primary unilateral PPV between April 2018 and July 2020, with ≥ 12 months of follow-up. IOP in vitrectomized and fellow eyes was analyzed preoperatively, at 3 months, and at final visit. OH was defined as the need for IOP-lowering medication; IOP was also analyzed as a continuous variable. Baseline and intraoperative factors were evaluated using cohort and matched case-control designs. Median follow-up was 28 months. Early and late OH occurred in 28.2% and 15.3% of vitrectomized eyes. Retinal detachment (RD) increased the risk of early OH fourfold (OR 4.16; p < 0.001). Higher preoperative IOP in the fellow eye predicted both early (OR 1.17; p = 0.003) and late OH (OR 1.18; p = 0.007). Postoperatively, vitrectomized eyes had higher IOP at all timepoints. Glaucoma developed in 6.5% of vitrectomized vs. 1.4% of fellow eyes (p = 0.008). PPV is associated with sustained IOP elevation and increased OH risk. RD and fellow eye IOP are relevant predictors. Long-term monitoring is essential to prevent glaucoma, especially in high-risk patients.
为评估玻璃体切割术（PPV）后眼内压（IOP）变化及高眼压症（OH）的发生情况，评估短期和长期结局及危险因素。这是一项对2018年4月至2020年7月期间接受原发性单侧PPV且随访时间≥12个月的216例患者（432只眼）的回顾性研究。对接受玻璃体切割术的患眼和对侧眼在术前、术后3个月及末次随访时的IOP进行分析。OH定义为需要使用降低IOP的药物；IOP也作为连续变量进行分析。使用队列研究和匹配病例对照设计评估基线和术中因素。中位随访时间为28个月。接受玻璃体切割术的眼中，早期和晚期OH的发生率分别为28.2%和15.3%。视网膜脱离（RD）使早期OH的风险增加四倍（OR 4.16；p＜0.001）。对侧眼术前较高的IOP可预测早期（OR 1.17；p = 0.003）和晚期OH（OR 1.18；p = 0.007）。术后，接受玻璃体切割术的患眼在所有时间点的IOP均较高。接受玻璃体切割术的眼中青光眼的发生率为6.5%，而对侧眼中为1.4%（p = 0.008）。PPV与IOP持续升高及OH风险增加相关。RD和对侧眼IOP是相关预测因素。长期监测对于预防青光眼至关重要，尤其是在高危患者中。
