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通过深度学习和主题建模实现临床决策的变革,以优化诊疗路径。

Revolutionizing clinical decision making through deep learning and topic modeling for pathway optimization.

作者信息

Tianzhao Liu, Jinzhi He, Rong Zhou, Jun Song, Hailong Liu, Yan Liang

机构信息

School of Resources and Environment, Shensi Lab, University of Electronic Science and Technology of China, Chengdu, China.

Peking University Shenzhen Hospital, Shenzhen, China.

出版信息

Sci Rep. 2025 Aug 6;15(1):28787. doi: 10.1038/s41598-025-12679-z.

DOI:10.1038/s41598-025-12679-z
PMID:40770243
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12328816/
Abstract

Optimizing clinical pathways is pivotal for enhancing healthcare delivery, yet traditional methods are increasingly insufficient in the face of complex, personalized medical demands. This paper introduces an innovative optimization framework that fuses Latent Dirichlet Allocation (LDA) topic modeling with Bidirectional Long Short-Term Memory (BiLSTM) networks to address the complexities of modern healthcare. The LDA component elucidates key diagnostic and treatment patterns from clinical narratives, while the BiLSTM network adeptly captures the temporal progression of patient care. Our model was validated against a real-world medical dataset, achieving remarkable results with an accuracy of over 90%, precision exceeding 28% improvement, recall with a 21% enhancement, and an F1 score that reflects a 25% increase over existing models. These results were obtained through comparative analysis with established models such as DeepCare, Doctor AI, and LSTM variants, showcasing the superior predictive capabilities of our LDA-BiLSTM integrated approach. This study not only advances the academic discourse on clinical pathway management but also presents a tangible tool for healthcare practitioners, promising a significant impact on the customization and efficacy of clinical pathways, thereby enhancing patient care and satisfaction.

摘要

优化临床路径对于提高医疗服务质量至关重要,但面对复杂的个性化医疗需求,传统方法越来越显得不足。本文介绍了一种创新的优化框架,该框架将潜在狄利克雷分配(LDA)主题建模与双向长短期记忆(BiLSTM)网络相结合,以应对现代医疗保健的复杂性。LDA组件从临床叙述中阐明关键的诊断和治疗模式,而BiLSTM网络则巧妙地捕捉患者护理的时间进展。我们的模型针对真实世界的医疗数据集进行了验证,取得了显著成果,准确率超过90%,精确率提高超过28%,召回率提高21%,F1分数比现有模型提高25%。这些结果是通过与DeepCare、Doctor AI和LSTM变体等既定模型进行比较分析得出的,展示了我们的LDA-BiLSTM集成方法卓越的预测能力。这项研究不仅推动了临床路径管理的学术讨论,还为医疗从业者提供了一个切实可行的工具,有望对临床路径的定制和疗效产生重大影响,从而提高患者护理水平和满意度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3193/12328816/956157497cfb/41598_2025_12679_Figb_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3193/12328816/c98849f9fc2c/41598_2025_12679_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3193/12328816/826a0691c91b/41598_2025_12679_Fig2_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3193/12328816/54ffafe4743f/41598_2025_12679_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3193/12328816/cfd8f849e083/41598_2025_12679_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3193/12328816/517d11bd7773/41598_2025_12679_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3193/12328816/4a5f68059a10/41598_2025_12679_Figa_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3193/12328816/956157497cfb/41598_2025_12679_Figb_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3193/12328816/c98849f9fc2c/41598_2025_12679_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3193/12328816/826a0691c91b/41598_2025_12679_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3193/12328816/b5f74723c2c5/41598_2025_12679_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3193/12328816/54ffafe4743f/41598_2025_12679_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3193/12328816/cfd8f849e083/41598_2025_12679_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3193/12328816/517d11bd7773/41598_2025_12679_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3193/12328816/4a5f68059a10/41598_2025_12679_Figa_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3193/12328816/956157497cfb/41598_2025_12679_Figb_HTML.jpg

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