Liu Xianfeng, Lv Shanshan, Li Guixia, Guo Xuying, Zheng Jing
Cardiac Surgery Intensive Care Unit, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.
BMC Cardiovasc Disord. 2025 Aug 6;25(1):583. doi: 10.1186/s12872-025-05064-1.
Severe aortic stenosis (AS) significantly impacts patients' quality of life (QoL). Although transcatheter aortic valve replacement (TAVR) has emerged as a less invasive treatment option, its effects on QoL and associated factors remain inadequately explored. To evaluate QoL and its associated factors in patients with AS following TAVR.
This cross-sectional study enrolled patients aged 25 years and older who underwent TAVR via transfemoral, transapical, or carotid artery approaches between January 2024 and February 2024. QoL was measured via the validated Chinese Cardiovascular Patients QoL Assessment Questionnaire. Clinical, demographic, and behavioral data were collected through structured interviews and medical record review. Stepwise multiple linear regression analysis was performed to identify predictors of QoL across total and domain-specific scores.
A total of 102 patients were included, with 56.86% aged 71-80 years and 59.80% male. The majority of patients underwent TAVR via the transapical approach (87.25%). Hospital stay duration, medication adherence, and the age-adjusted Charlson Comorbidity Index (Age-CCI) score were identified as significant predictors of total QoL. Specifically, longer hospital stays and higher Age-CCI scores were negatively associated with QoL, whereas good medication adherence was positively associated with QoL. Additionally, regular physical exercise and hospital stay duration emerged as significant predictors across several QoL domains.
QoL following TAVR is influenced by both clinical and behavioral factors, including hospital stay length, medication adherence, and comorbidity burden. Targeted interventions addressing these modifiable factors may enhance patient recovery and improve long-term QoL outcomes.
重度主动脉瓣狭窄（AS）对患者的生活质量（QoL）有显著影响。尽管经导管主动脉瓣置换术（TAVR）已成为一种侵入性较小的治疗选择，但其对生活质量的影响及相关因素仍未得到充分研究。旨在评估经导管主动脉瓣置换术（TAVR）后AS患者的生活质量及其相关因素。
这项横断面研究纳入了2024年1月至2024年2月期间通过股动脉、经心尖或颈动脉途径接受TAVR的25岁及以上患者。通过经过验证的中国心血管病患者生活质量评估问卷来测量生活质量。通过结构化访谈和病历审查收集临床、人口统计学和行为数据。进行逐步多元线性回归分析，以确定总体和特定领域得分中生活质量的预测因素。
共纳入102例患者，其中56.86%年龄在71 - 80岁之间，59.80%为男性。大多数患者通过经心尖途径接受TAVR（87.25%）。住院时间、药物依从性和年龄调整后的Charlson合并症指数（Age - CCI）得分被确定为总体生活质量的重要预测因素。具体而言，住院时间越长和Age - CCI得分越高与生活质量呈负相关，而良好的药物依从性与生活质量呈正相关。此外，规律的体育锻炼和住院时间在多个生活质量领域中成为重要的预测因素。
TAVR后的生活质量受临床和行为因素影响，包括住院时间、药物依从性和合并症负担。针对这些可改变因素的有针对性干预可能会促进患者康复并改善长期生活质量结果。
