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Use of DTPA for increasing the rate of elimination of plutonium-238 and americium-241 from rodents after their inhalation as the nitrates.

作者信息

Stather J W, Stradling G N, Gray S A, Moody J, Hodgson A

出版信息

Hum Toxicol. 1985 Nov;4(6):573-82. doi: 10.1177/096032718500400603.

DOI:10.1177/096032718500400603
PMID:4077069
Abstract

This study has shown that: both inhaled (2 mumol/kg) and injected (30 mumol/kg) diethylenetriaminepenta-acetic acid (DTPA) can reduce the lung deposit of 238 Pu and 241 Am inhaled as nitrate to about 1% of that in untreated controls; injection of DTPA is more effective than aerosolized DTPA for reducing deposits of 238Pu and 241Am in the liver and skeleton; combined treatment involving early inhalation of DTPA followed by repeated intravenous injections is likely to be the most effective treatment for workers who have accidentally inhaled plutonium and americium nitrates.

摘要

相似文献

1
Use of DTPA for increasing the rate of elimination of plutonium-238 and americium-241 from rodents after their inhalation as the nitrates.
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2
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2
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J Pharm Sci. 2014 May;103(5):1563-71. doi: 10.1002/jps.23932. Epub 2014 Mar 11.