巴比妥酸盐/乙醇中毒协同作用的热力学解释

Thermodynamic interpretation of synergism in barbiturate/ethanol poisoning.

作者信息

King L A

出版信息

Hum Toxicol. 1985 Nov;4(6):633-5. doi: 10.1177/096032718500400611.

Abstract

Ethanol and barbiturate drugs behave as non-specific depressants of the central nervous system (Ferguson substances). Their interaction can therefore be understood quantitatively by the application of thermodynamic theory. It is unnecessary to postulate specific biochemical mechanisms for the observed synergism. A similar situation should exist for any pair of Ferguson substances.

摘要

乙醇和巴比妥类药物表现为中枢神经系统的非特异性抑制剂（弗格森物质）。因此，它们之间的相互作用可以通过应用热力学理论进行定量理解。对于观察到的协同作用，无需假定特定的生化机制。任何一对弗格森物质都应存在类似情况。