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中药在糖尿病性心肌病中的治疗潜力:综述

Therapeutic potential of traditional Chinese medicine in diabetic cardiomyopathy: a review.

作者信息

Li Wencan, Liu Xiang, Liu Zheng, Xing Qichang, Liu Renzhu, Wu Qinxuan, Zhang Jiani

机构信息

Department of Clinical Pharmacy, Xiangtan Central Hospital (The Affiliated Hospital of Hunan University), Xiangtan, Hunan, China.

Hunan Provincial Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations, the "Double-First Class" Application Characteristic Discipline of Hunan Province (Pharmaceutical Science), Changsha Medical University, Changsha, Hunan, China.

出版信息

Front Endocrinol (Lausanne). 2025 Jul 23;16:1532565. doi: 10.3389/fendo.2025.1532565. eCollection 2025.

Abstract

Diabetic cardiomyopathy (DCM) is a common cardiovascular complication that could lead to changes in cardiac structure and function. It is one of the leading causes of death in diabetic patients. Due to the complex pathogenesis of DCM, there is currently no specific drug or prophylactic agent to treat DCM, so there is an urgent need to identify new therapeutic agents or complementary and alternative therapies for DCM. Although Traditional Chinese medicine (TCM) has some limitations, it has the unique advantages of multi-level, multi-target and few side effects, which could effectively deal with the complex pathological mechanism of DCM. Growing evidence suggests that inflammation, oxidative stress, myocardial fibrosis and autophagy are the main pathological mechanisms of DCM. This study will shed light on the prospects of TCM treatment of DCM from the above perspective in order to provide more ideas and evidence for the clinical use of TCM for the prevention and treatment of DCM.

摘要

糖尿病性心肌病(DCM)是一种常见的心血管并发症,可导致心脏结构和功能发生改变。它是糖尿病患者死亡的主要原因之一。由于DCM发病机制复杂,目前尚无治疗DCM的特效药物或预防药物,因此迫切需要寻找治疗DCM的新治疗药物或补充替代疗法。虽然传统中药(TCM)有一定局限性,但它具有多层次、多靶点、副作用少的独特优势,能够有效应对DCM复杂的病理机制。越来越多的证据表明,炎症、氧化应激、心肌纤维化和自噬是DCM的主要病理机制。本研究将从上述角度探讨中药治疗DCM的前景,为中药临床防治DCM提供更多思路和依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7071/12325053/b3ffe266be10/fendo-16-1532565-g001.jpg

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