The perioperative patient-centered comfort management (2P2CM) model introduces a transformative approach to surgical care, prioritizing patient comfort, psychological well-being, and satisfaction across the perioperative continuum. Unlike traditional models that focus primarily on clinical outcomes, the 2P2CM model emphasizes a holistic framework that integrates preoperative, intraoperative, and postoperative interventions tailored to individual patient needs. This review synthesizes the emerging evidence supporting the 2P2CM model, which aims to alleviate preoperative anxiety, optimize postoperative pain management, and tailor care to individual patient needs. The model integrates contributions from multiple disciplines, leveraging multimodal analgesia, personalized pain management strategies, and nonpharmacological interventions to enhance patient outcomes and reduce reliance on opioids. A key strength of the 2P2CM model lies in its interdisciplinary approach, incorporating insights from anesthesiology, nursing, psychology, and physical therapy to enhance recovery and minimize opioid dependence. By emphasizing shared decision-making and patient-reported outcomes, the 2P2CM model addresses the holistic needs of surgical patients, from preoperative anxiety to postoperative recovery. The review highlights the potential of this model to improve patient satisfaction, reduce postoperative complications, and establish a new standard for patient-centered perioperative care. Future research is necessary to further refine the components of the 2P2CM model and assess its long-term efficacy across a variety of surgical contexts.