术后认知功能障碍——当前研究进展
Postoperative cognitive dysfunction-current research progress.
作者信息
Zhao Qi, Wan Hui, Pan Hui, Xu Yiquan
机构信息
Department of Anesthesiology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.
出版信息
Front Behav Neurosci. 2024 Jan 30;18:1328790. doi: 10.3389/fnbeh.2024.1328790. eCollection 2024.
Abstract
Postoperative cognitive dysfunction (POCD) commonly occurs after surgery, particularly in elderly individuals. It is characterized by a notable decline in cognitive performance, encompassing memory, attention, coordination, orientation, verbal fluency, and executive function. This reduction in cognitive abilities contributes to extended hospital stays and heightened mortality. The prevalence of POCD can reach 40% within 1 week following cardiovascular surgery and remains as high as 17% 3 months post-surgery. Furthermore, POCD exacerbates the long-term risk of Alzheimer's disease (AD). As a result, numerous studies have been conducted to investigate the molecular mechanisms underlying POCD and potential preventive strategies. This article provides a review of the research progress on POCD.
摘要
术后认知功能障碍（POCD）常见于手术后，尤其是老年患者。其特征是认知能力显著下降，包括记忆、注意力、协调能力、定向力、语言流畅性和执行功能。认知能力的这种下降会导致住院时间延长和死亡率升高。POCD的患病率在心血管手术后1周内可达40%，术后3个月仍高达17%。此外，POCD会增加患阿尔茨海默病（AD）的长期风险。因此，人们进行了大量研究来探究POCD的分子机制和潜在的预防策略。本文对POCD的研究进展进行综述。
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