Schnapp Lynn M
Madison, WI.
Trans Am Clin Climatol Assoc. 2025;135:52-59.
Pericytes are specialized, mural cells essential to vascular integrity and homeostasis, with emerging roles in lung injury, fibrosis, and viral pathology. Situated around capillaries, pericytes can transition into myofibroblast-like cells and contribute to extracellular matrix (ECM) deposition following lung injury. This review delves into pericyte biology in the lung, highlighting their contributions to fibrotic processes, immune response mediation, and potential as viral reservoirs. Experimental insights from murine models and human lung pericytes underscore their dual function in structural repair and immune signaling. Here, we explore the impact of pericyte plasticity on fibrosis and immune dynamics, evaluate their interactions with viruses, and discuss their potential as therapeutic targets in lung disease. A comprehensive understanding of pericyte plasticity and heterogeneity could pave the way for novel treatments targeting fibrosis and virus-induced lung pathology.
周细胞是对血管完整性和内环境稳定至关重要的特殊壁细胞，在肺损伤、纤维化和病毒病理学中发挥着新出现的作用。周细胞位于毛细血管周围，在肺损伤后可转变为肌成纤维细胞样细胞并促进细胞外基质（ECM）沉积。本综述深入探讨了肺中的周细胞生物学，强调了它们对纤维化过程、免疫反应介导的贡献以及作为病毒储存库的潜力。来自小鼠模型和人肺周细胞的实验见解强调了它们在结构修复和免疫信号传导中的双重功能。在此，我们探讨周细胞可塑性对纤维化和免疫动力学的影响，评估它们与病毒的相互作用，并讨论它们作为肺部疾病治疗靶点的潜力。对周细胞可塑性和异质性的全面理解可能为针对纤维化和病毒诱导的肺部病理学的新疗法铺平道路。
