Huang Hui-Qiong, Yang Lu, Li Qing-Li, Sun Chun-Tang, Gong Feng-Ming
Department of Gynecology and Obstetrics, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
World J Clin Cases. 2025 Aug 6;13(22):104643. doi: 10.12998/wjcc.v13.i22.104643.
Serous carcinoma of the uterine cervix (USCC) represents a rare subtype of cervical adenocarcinoma, classified into human papillomavirus (HPV)-independent and HPV-associated types. It is characterized by high invasiveness and poor prognosis, with limited global reports on this condition.
A 58-year-old Chinese woman presented with painless vaginal bleeding after sexual intercourse, which appeared as droplets. HPV testing and histopathological analysis confirmed the diagnosis of HPV-associated primary serous carcinoma of the USCC. The patient underwent radical hysterectomy and was diagnosed with primary serous carcinoma of the uterine cervix, stage III C2 (FIGO 2018). A multimodal treatment approach, including surgery, radiotherapy, and chemotherapy, was administered. After additional concurrent chemoradiotherapy and three cycles of chemotherapy, the patient showed no evidence of disease progression and achieved long-term survival for 53 months.
USCC is a rare and aggressive malignancy. Upon diagnosis, multimodal treatment strategies, including surgery, radiotherapy, and chemotherapy, can effectively prolong patient survival and improve prognosis.
子宫颈浆液性癌（USCC）是宫颈腺癌的一种罕见亚型，分为人乳头瘤病毒（HPV）非依赖性和HPV相关性类型。其特点是侵袭性高、预后差，全球关于这种疾病的报道有限。
一名58岁中国女性出现性交后无痛性阴道点滴出血。HPV检测和组织病理学分析确诊为HPV相关性原发性子宫颈浆液性癌。患者接受了根治性子宫切除术，被诊断为子宫颈原发性浆液性癌，III C2期（FIGO 2018）。采用了包括手术、放疗和化疗在内的多模式治疗方法。在额外进行同步放化疗和三个周期化疗后，患者未出现疾病进展迹象，并实现了53个月的长期生存。
子宫颈浆液性癌是一种罕见且侵袭性强的恶性肿瘤。确诊后，包括手术、放疗和化疗在内的多模式治疗策略可有效延长患者生存期并改善预后。
