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[胃肠外注射酪蛋白水解物对不同程度胃腺去神经支配状态下胃分泌活动的影响]

[Effect of a parenterally administered casein hydrolysate on the secretory activity of the stomach with different degrees of gastric gland denervation].

作者信息

Vasilevskaia L S, Klimashina T A, Laktaeva T V

出版信息

Vopr Pitan. 1977 Jan-Feb(1):41-4.

PMID:407721
Abstract

Experiments carried out on dogs helped ascertain the casein hydrolysate capable of provoking gastric secretion both with retained gastric innervation and without preservation of the vagal and sympathetic innervation. As this been shown earlier the effect of nitrous substances on the gastric secretion is realized mainly through the agency of the nervous mechanism. The observed secretion in dogs with denervated isolated pouches, however, occuring in response to administration of casein hydrolysate may be explained by mobilization of gastrin under the effect of nervous impulses and its action on the gastric glands. This assumption has been confirmed by tests carried out with the inhibitorglycomacropeptide which inhibits mainly the action of gastrin on the gastric glands.

摘要

在狗身上进行的实验有助于确定酪蛋白水解物,它在保留胃神经支配以及未保留迷走神经和交感神经支配的情况下均能刺激胃液分泌。如先前所示,亚硝物质对胃液分泌的影响主要通过神经机制实现。然而,在去神经支配的孤立袋状胃的狗身上观察到的、对酪蛋白水解物给药产生的分泌,可能是由于神经冲动作用下胃泌素的动员及其对胃腺的作用来解释。用主要抑制胃泌素对胃腺作用的抑制性糖巨肽进行的试验证实了这一假设。

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