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卢旺达获得有限重症监护的情况与死亡风险:一项前瞻性队列研究。

Access to Limited Critical Care and Risk of Mortality in Rwanda: A Prospective Cohort Study.

作者信息

Mezei Alex, Hitayezu Donatien, Gilman Tyler, Bone Jeffrey, Hategaka Celestin, Murthy Srinivas, McKnight Marla, Twagirumugabe Theogene

机构信息

Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

Department of Anaesthesia and Critical Care Medicine, University of Rwanda, Butare, Rwanda.

出版信息

Crit Care Explor. 2025 Aug 7;7(8):e1298. doi: 10.1097/CCE.0000000000001298. eCollection 2025 Aug 1.

DOI:10.1097/CCE.0000000000001298
PMID:40772867
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12333700/
Abstract

IMPORTANCE

There is a large discrepancy between need and access to critical care in low- and middle-income countries. Little is known about what subgroups of patients are being prioritized for critical care.

OBJECTIVES

The primary objective was to assess what clinical, demographic, and socioeconomic variables were associated with timely ICU admission. Secondary objectives included determining the rate of ICU admission among patients who met admission criteria, inpatient mortality, and length of stay.

DESIGN

Prospective cohort study.

SETTING AND PARTICIPANTS

All adult patients meeting ICU admission criteria at the University Teaching Hospital of Butare, Huye, Rwanda.

MAIN OUTCOMES AND MEASURES

The primary outcome was the proportion of patients admitted to ICU within 24 hours of being identified as critically ill. A multivariable logistic regression model was used to assess whether clinical, demographic, or socioeconomic factors are associated with timely ICU admission. Secondary outcomes were the proportion of patients admitted to ICU at any time, inpatient mortality, and length of stay.

RESULTS

Three hundred eighteen patients were enrolled between January 24, 2024, and June 3, 2024. Eighty-eight (27.7%) were admitted to ICU within 24 hours. Requiring ICU for postoperative recovery (odds ratio [OR], 8.21; 95% CI, 3.64-19.8), obstetric patients (OR, 2.43; 95% CI, 0.92-6.41), and ICU bed availability (OR, 1.26; 95% CI, 1.02-1.55) increased the odds of timely ICU admission in multivariable analysis. Socioeconomic status, gender, and social connections had minimal association with ICU admission, with wide CIs. The inpatient mortality rate was 44.0% and average length of stay was 14 days.

CONCLUSIONS AND RELEVANCE

Obstetric and postoperative patients are prioritized for ICU admission. There is a large unmet need for critical care in Rwanda, and mortality among critically ill patients is high.

摘要

重要性

低收入和中等收入国家在重症监护的需求与可及性之间存在巨大差距。对于哪些患者亚组被优先安排接受重症监护,人们了解甚少。

目的

主要目的是评估哪些临床、人口统计学和社会经济变量与及时入住重症监护病房(ICU)相关。次要目的包括确定符合入院标准的患者的ICU入住率、住院死亡率和住院时长。

设计

前瞻性队列研究。

地点和参与者

卢旺达胡耶省布塔雷大学教学医院所有符合ICU入院标准的成年患者。

主要结局和衡量指标

主要结局是被确定为危重症患者后24小时内入住ICU的患者比例。使用多变量逻辑回归模型评估临床、人口统计学或社会经济因素是否与及时入住ICU相关。次要结局是任何时间入住ICU的患者比例、住院死亡率和住院时长。

结果

2024年1月24日至2024年6月3日期间共纳入318例患者。88例(27.7%)在24小时内入住ICU。多变量分析显示,术后恢复需要ICU(比值比[OR],8.21;95%置信区间[CI],3.64 - 19.8)、产科患者(OR,2.43;95% CI,0.92 - 6.41)以及ICU床位可用性(OR,1.26;95% CI,1.02 - 1.55)增加了及时入住ICU的几率。社会经济地位、性别和社会关系与ICU入住的关联极小,置信区间较宽。住院死亡率为44.0%,平均住院时长为14天。

结论及意义

产科和术后患者在ICU入院方面被优先考虑。卢旺达对重症监护存在大量未满足的需求,危重症患者的死亡率很高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/145c/12333700/aae25fa7006d/cc9-7-e1298-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/145c/12333700/aae25fa7006d/cc9-7-e1298-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/145c/12333700/aae25fa7006d/cc9-7-e1298-g001.jpg

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The African Critical Illness Outcomes Study (ACIOS): a point prevalence study of critical illness in 22 nations in Africa.非洲危重症结局研究(ACIOS):一项对非洲22个国家危重症的现况研究。
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Critical care delivery across health care systems in low-income and low-middle-income country settings: A systematic review.
在低收入和中低收入国家卫生系统中提供重症监护:系统评价。
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Causes and Outcomes of Intensive Care Admission Refusals: A Retrospective Audit from a Rural Teaching Hospital in Eastern Cape, South Africa.重症监护入院拒绝的原因及结果:来自南非东开普省一家农村教学医院的回顾性审计
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Pattern of diseases and clinical outcomes in medical intensive care unit at a tertiary hospital in northeastern Tanzania: A three-year retrospective study.坦桑尼亚东北部一家三级医院重症监护病房的疾病模式和临床结局:一项为期三年的回顾性研究。
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The Predictive Role of Modified Early Warning Score in 174 Hematological Patients at the Point of Transfer to the Intensive Care Unit.改良早期预警评分在174例血液科患者转入重症监护病房时的预测作用
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Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.拯救脓毒症运动:2021年脓毒症和脓毒性休克国际管理指南
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