慢性肾衰竭患者手部指骨的早期骨骼变化

Early skeletal changes of the hand phalanges in patients with chronic renal failure.

作者信息

Bedani P L, Tamarozzi R, Pinna L, Gilli P, Perini L, Farinelli A

出版信息

Int J Artif Organs. 1985 Nov;8(6):325-30.

Abstract

Appearance time and the severity of skeletal changes in patients with chronic renal failure are still not well defined. In 61 patients with incipient to advanced renal insufficiency (glomerular filtration rate 70 to 5 ml/min X 1.73 m2), bone alterations (acro-osteolysis, subeperiosteal and intracortical resorption) were mammographically studied in hand phalanges. A high correlation (p less than 0.001) was found between the radiological score and the severity of the renal insufficiency. The earliest changes of renal osteodystrophy occurred in the tufts. Biopsy specimens were taken from the iliac crest in 22 patients. Qualitative bone histology correlated significantly (p less than 0.001) with the total radiological score. Mammography offers an effective and non-invasive means of studying early skeletal changes in patients with chronic renal failure.

摘要

慢性肾衰竭患者骨骼变化的出现时间和严重程度仍未明确界定。对61例初发至晚期肾功能不全（肾小球滤过率为70至5 ml/min×1.73 m²）的患者，对手部指骨进行了乳房X线摄影研究，观察骨改变（肢端骨质溶解、骨膜下和皮质内吸收）情况。发现放射学评分与肾功能不全的严重程度之间存在高度相关性（p<0.001）。肾性骨营养不良最早的变化出现在指端。对22例患者进行了髂嵴活检。定性骨组织学与总放射学评分显著相关（p<0.001）。乳房X线摄影为研究慢性肾衰竭患者早期骨骼变化提供了一种有效且非侵入性的方法。