Nerattini Matilde, Berti Valentina, Matthews Dawn C, Williams Schantel, Andy Caroline, Fauci Francesca, Boneu Camila, Ajila Trisha, Pahlajani Silky, Battista Michael, Andrews Randolph, Pupi Alberto, Osborne Joseph R, Fink Matthew, Brinton Roberta Diaz, Dyke Jonathan P, Mosconi Lisa
Department of Neurology, Weill Cornell Medicine, New York, NY, USA.
Department of Biomedical Experimental and Clinical Sciences "Mario Serio", University of Florence, Viale Morgagni, 50, Florence, 50134, FI, Italy.
Eur J Nucl Med Mol Imaging. 2025 Aug 7. doi: 10.1007/s00259-025-07470-1.
Positron emission tomography (PET) with 16α-[F]fluoro-17β-estradiol (F-FES) allows for the in vivo assessment of brain estrogen receptor (ER) expression. This study examines brain F-FES uptake to define an optimal acquisition time for static late images suitable for clinical application.
Fifty-five healthy, 40-65-year-old women at different endocrine aging stages (n = 18 premenopause, n = 18 perimenopause, and n = 19 postmenopause) underwent dynamic 90-minute F-FES PET imaging. We obtained regional brain distribution volume ratios (DVR) based on Logan graphical analysis and standardized uptake value ratios (SUVR) at five 20 min increments (30-50, 40-60, 50-70, 60-80 and 70-90 min post-injection), using the cerebellar gray matter as the reference. We used reliability analysis and automated variable selection procedures to identify the most consistent SUVR time windows relative to DVR. In sensitivity analyses, we tested for group differences and associations with cognitive performance in these SUVR time frames. Analysis focused on the pituitary gland, which has demonstrated specific binding. Exploratory ER-rich regions of interest (ROI) included hypothalamus, hippocampus, amygdala, caudate, frontal and cingulate cortex.
SUVR measurements exhibited stronger associations with DVR at earlier compared to later time frames. Specifically, the optimal SUVR time frames in pituitary, and in most exploratory ROIs, were predominantly within the 30-50 and 40-60 min intervals. Both intervals were effective at differentiating postmenopausal versus premenopausal groups, and the 30-50 min window showed more significant associations with cognitive scores.
Examination of quantitative and simplified methods for analysis of brain F-FES PET uptake identified the 30-60 min SUVR window as performing optimally relative to DVR measures. This provides a practical method for quantifying relative pituitary tracer retention in clinical populations.
使用16α-[F]氟-17β-雌二醇（F-FES）进行正电子发射断层扫描（PET）可在体内评估脑雌激素受体（ER）的表达。本研究检测脑F-FES摄取情况，以确定适合临床应用的静态晚期图像的最佳采集时间。
55名年龄在40 - 65岁处于不同内分泌衰老阶段的健康女性（18名绝经前、18名围绝经期和19名绝经后）接受了90分钟的动态F-FES PET成像。我们基于洛根图形分析获得区域脑分布体积比（DVR），并在注射后每隔20分钟（30 - 50、40 - 60、50 - 70、60 - 80和70 - 90分钟）以小脑灰质为参考获得标准化摄取值比（SUVR）。我们使用可靠性分析和自动变量选择程序来确定相对于DVR最一致的SUVR时间窗。在敏感性分析中，我们测试了这些SUVR时间框架内的组间差异以及与认知表现的关联。分析重点关注已显示有特异性结合的垂体。富含ER的探索性感兴趣区域（ROI）包括下丘脑、海马体、杏仁核、尾状核、额叶和扣带回皮质。
与较晚时间框架相比，SUVR测量在较早时间框架与DVR表现出更强的相关性。具体而言，垂体以及大多数探索性ROI中的最佳SUVR时间框架主要在30 - 50和40 - 60分钟间隔内。这两个间隔在区分绝经后组与绝经前组方面均有效，且30 - 50分钟窗口与认知分数的关联更显著。
对脑F-FES PET摄取分析的定量和简化方法的研究确定，相对于DVR测量，30 - 60分钟的SUVR窗口表现最佳。这为临床人群中定量垂体示踪剂相对滞留提供了一种实用方法。
Zotero 插件