Nguyen Quyen Thuy, Tran An Viet, Nguyen Bao The, Nguyen Hoa Thai, Thai Nhung Thi Hong, Phan Hen Huu
Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam.
University of Medicine and Pharmacy, Hue University, Thua Thien Hue, Vietnam.
JMIR Cardio. 2025 Aug 7;9:e76850. doi: 10.2196/76850.
Apolipoprotein B (APOB) rs676210 polymorphism has been associated with altered lipid metabolism and cardiovascular risk in various populations; however, data from Vietnamese populations remain limited.
This study aimed to investigate the association of the APOB rs676210 variant with lipid profiles among Vietnamese individuals newly diagnosed with elevated low-density lipoprotein cholesterol (LDL-C).
A cross-sectional study was conducted among 69 Vietnamese adults newly diagnosed with elevated LDL-C (≥130 mg/dL) at a tertiary hospital in Southern Vietnam. Participants were genotyped for APOB rs676210 using real-time polymerase chain reaction (PCR) with allele-specific probes. Lipid profile components, including LDL-C, high-density lipoprotein cholesterol (HDL-C), non-HDL-C, and ApoB, were compared across genotype groups (AA vs GA/GG) and alleles (A vs G). Statistical analyses involved t tests, chi-square tests, and multivariable linear regression adjusted for age, sex, the BMI, and diabetes. P<.05 was considered statistically significant.
Of the 69 participants, 32 (46.4%) carried the AA genotype, while 37 (53.6%) carried the GA or the GG genotype. The AA genotype was associated with significantly higher LDL-C (mean 5.19, SD 0.95, vs mean 4.37, SD 0.97, mmol/L; P<.001), non-HDL-C (mean 5.94, SD 1.08, vs mean 5.31, SD 1.22 mmol/L; P=.03), and ApoB (mean 149.5, SD 26.3, vs mean 136.9, SD 15.2, mg/dL; P=.02) and lower HDL-C (mean 1.26, SD 0.31, vs mean 1.44, SD 0.39, mmol/L; P=.03) compared to the GA/GG genotype. Allele-based analysis showed that carriers of the A allele (98/138, 71%) also had higher LDL-C (mean 4.91, SD 1.02, vs mean 4.36, SD 0.97, mmol/L; P=.004) and ApoB (mean 145.6, SD 23.2, vs mean 135.9, SD 16.0, mg/dL; P=.02) than G allele carriers (40/138, 29%). These associations remained significant after multivariate adjustment.
APOB rs676210 polymorphism is associated with significant differences in lipid profiles among Vietnamese adults with elevated LDL-C. Specifically, the A allele and the AA genotype confer a more atherogenic profile, suggesting potential utility as a genetic marker in lipid screening and personalized cardiovascular risk management in this population.
载脂蛋白B（APOB）rs676210多态性与不同人群脂质代谢改变及心血管风险相关；然而，越南人群的数据仍然有限。
本研究旨在调查新诊断为低密度脂蛋白胆固醇（LDL-C）升高的越南个体中APOB rs676210变异与血脂谱的关联。
在越南南部一家三级医院对69名新诊断为LDL-C升高（≥130 mg/dL）的越南成年人进行了一项横断面研究。使用等位基因特异性探针的实时聚合酶链反应（PCR）对参与者的APOB rs676210进行基因分型。比较各基因型组（AA与GA/GG）和等位基因（A与G）之间的血脂谱成分，包括LDL-C、高密度脂蛋白胆固醇（HDL-C）、非HDL-C和载脂蛋白B。统计分析包括t检验、卡方检验以及对年龄、性别、体重指数和糖尿病进行校正的多变量线性回归。P<0.05被认为具有统计学意义。
69名参与者中，32名（46.4%）携带AA基因型，37名（53.6%）携带GA或GG基因型。与GA/GG基因型相比，AA基因型与显著更高的LDL-C（均值5.19，标准差0.95，对比均值4.37，标准差0.97，mmol/L；P<0.001）、非HDL-C（均值5.94，标准差1.08，对比均值5.31，标准差1.22 mmol/L；P=0.03）和载脂蛋白B（均值149.5，标准差26.3，对比均值136.9，标准差15.2，mg/dL；P=0.02）以及更低的HDL-C（均值1.26，标准差0.31，对比均值1.44，标准差0.39，mmol/L；P=0.03）相关。基于等位基因的分析表明，A等位基因携带者（98/138，71%）的LDL-C（均值4.91，标准差1.02，对比均值4.36，标准差0.97，mmol/L；P=0.004）和载脂蛋白B（均值145.6，标准差23.2，对比均值135.9，标准差16.0，mg/dL；P=0.02）也高于G等位基因携带者（40/138，29%）。多变量调整后这些关联仍然显著。
APOB rs676210多态性与LDL-C升高的越南成年人血脂谱的显著差异相关。具体而言，A等位基因和AA基因型具有更强的致动脉粥样硬化特征，提示其在该人群脂质筛查和个性化心血管风险管理中作为遗传标志物的潜在效用。
