Yoshioka M, Aoyama K, Matsushita T
Int J Vitam Nutr Res. 1985;55(3):301-7.
Spontaneously hypertensive rats (SH rats) were administered drinking water containing 0, 200 or 1000 ppm ascorbic acid with or without 0.5% NaCl and the usual laboratory stock diet for 130 days. The rats given ascorbic acid with or without 0.5% NaCl had a lower mean systolic blood pressure level than that of the respective control group. The difference in the mean blood pressure level from that of the control group was 18-19 mmHg for 200 ppm ascorbic acid group and 30-40 mmHg for 1000 ppm ascorbic acid group. The SH rats were shown to have some defects of ascorbic acid metabolism by lower tissue ascorbic acid levels in the liver, lung and adrenals, and by lower response of ascorbic acid synthesis to a xenobiotic than the Wistar Kyoto rats, which served as the normotensive control rats for SH rats. The abnormalities of ascorbic acid metabolism in the SH rats may be associated with, in part, their high blood pressure, because exogenous ascorbic acid prevented the blood pressure elevation of SH rats, but some other mechanism may also be involved in the effect of ascorbic acid on blood pressure.
自发性高血压大鼠（SH大鼠）饮用含0、200或1000 ppm抗坏血酸且添加或不添加0.5%氯化钠的饮用水，并给予常规实验室标准饮食，持续130天。给予含或不含0.5%氯化钠抗坏血酸的大鼠，其平均收缩压水平低于各自的对照组。200 ppm抗坏血酸组与对照组平均血压水平的差异为18 - 19 mmHg，1000 ppm抗坏血酸组为30 - 40 mmHg。与作为SH大鼠正常血压对照的Wistar Kyoto大鼠相比，SH大鼠肝脏、肺和肾上腺组织中的抗坏血酸水平较低，且抗坏血酸合成对外源生物的反应较低，表明SH大鼠存在一些抗坏血酸代谢缺陷。SH大鼠抗坏血酸代谢异常可能部分与其高血压有关，因为外源性抗坏血酸可防止SH大鼠血压升高，但抗坏血酸对血压的影响可能还涉及其他一些机制。
