Jensen L I, Dean P B, Nyman U, Golman K
Invest Radiol. 1985 Nov;20(8):867-70. doi: 10.1097/00004424-198511000-00016.
Iohexol and meglumine-sodium diatrizoate were injected intravenously into 18 pigs as either a 99:1 or 1:99 mixture. Blood samples were taken for 30 minutes and the concentration of each of the two contrast media was measured by means of a double labeling technique with 125I and 131I. Relative concentrations of iohexol were significantly higher during the first 3 minutes when it was injected as a moderately hyperosmolar (99% iohexol) solution than when it was injected as a very hyperosomolar (99% diatrizoate) solution. The greater intravascular dilution of the 99% diatrizoate solution by extravascular water may explain this finding as well as the significantly longer rapid disposition phase and the slightly lower distribution volume of iohexol.
将碘海醇和泛影葡胺钠以99:1或1:99的混合物静脉注射到18头猪体内。采集血样30分钟，采用125I和131I双标记技术测量两种造影剂各自的浓度。当碘海醇作为中等高渗（99%碘海醇）溶液注射时，在最初3分钟内其相对浓度显著高于作为极高渗（99%泛影葡胺）溶液注射时。99%泛影葡胺溶液被血管外水分更大程度的血管内稀释可能解释了这一发现，以及碘海醇明显更长的快速消除期和略低的分布容积。
