Lacomba Iñaki, López Antonio, Hervàs-Ayala Raquel, Coscollà Clara
Foundation for the Promotion of Health and Biomedical Research in the Valencia Region, FISABIO-Public Health, Avenida Catalunya 21, 46020, Valencia, Spain; Department of Analytical Chemistry, Univeristy of Valencia, Doctor Moliner 50, 46100, Burjassot, Spain.
Foundation for the Promotion of Health and Biomedical Research in the Valencia Region, FISABIO-Public Health, Avenida Catalunya 21, 46020, Valencia, Spain.
Food Chem Toxicol. 2025 Aug 6;205:115681. doi: 10.1016/j.fct.2025.115681.
Prenatal exposure to persistent organic pollutants (POPs) is a matter of great concern due to the vulnerability of the foetus. Seventeen polychlorinated dibenzo-p-dioxins and dibenzofurans (PCCD/Fs) and 12 dioxin-like polychlorinated biphenyls (dl-PCBs) were measured in meconium samples from 50 Spanish newborns using gas chromatography coupled to high-resolution mass spectrometry (GC-HRMS). Median concentrations (wet weight) of PCDD/Fs and dl-PCBs were 0.017 pg toxic equivalents (TEQ)/g and 0.0017 pg TEQ/g, respectively. Highly significant correlations were observed between some congeners of dl-PCBs and octachlorodibenzo-p-dioxin (OCDD), suggesting their similar sources and kinetic behaviour. Neonatal weight and gestational age were demographic parameters that influenced dl-PCB levels in meconium. Multiple regression analysis showed that consumption of ultra-processed foods contributed to the levels of several dl-PCBs in meconium. Our study concludes that meconium may be employed as a human matrix for assessing prenatal exposure to POPs and provides, for the first time, information about predictors of exposure and biomonitoring of dioxins and furans in biological meconium samples.
由于胎儿的脆弱性，产前暴露于持久性有机污染物（POPs）是一个备受关注的问题。使用气相色谱-高分辨率质谱联用仪（GC-HRMS）测定了50名西班牙新生儿胎粪样本中的17种多氯二苯并对二恶英和多氯二苯并呋喃（PCCD/Fs）以及12种二恶英类多氯联苯（dl-PCBs）。PCDD/Fs和dl-PCBs的中位浓度（湿重）分别为0.017 pg毒性当量（TEQ）/g和0.0017 pg TEQ/g。在某些dl-PCBs同系物与八氯二苯并对二恶英（OCDD）之间观察到高度显著的相关性，表明它们具有相似的来源和动力学行为。新生儿体重和胎龄是影响胎粪中dl-PCB水平的人口统计学参数。多元回归分析表明，超加工食品的消费导致了胎粪中几种dl-PCBs的含量升高。我们的研究得出结论，胎粪可用作评估产前POPs暴露的人体基质，并首次提供了有关生物胎粪样本中暴露预测因子以及二恶英和呋喃生物监测的信息。
