肺动脉高压模型与原发性高血压模型中的肾素-血管紧张素系统

The renin-angiotensin system in models of pulmonary arterial hypertension vs primary hypertension.

作者信息

Nakayama Yuki, Eguchi Satoru

机构信息

Heart Institute and Department of Surgery, Morsani College of Medicine, University of South Florida, Room 0815 MDD, 560 Channelside drive, Tampa, FL, 33602, USA.

出版信息

Hypertens Res. 2025 Aug 7. doi: 10.1038/s41440-025-02299-5.

DOI:10.1038/s41440-025-02299-5

PMID:40775063

Abstract

Animal models of pulmonary arterial hypertension (PAH) demonstrate up-regulation of the renin angiotensin system. However, no clinical data are available to support the efficacy of angiotensin II inhibition in treatment for PAH. In this mini review, we will update the knowledge regarding regulation of the RAS system in PAH compared to primary hypertension in order to seek better treatments against PAH.

摘要

肺动脉高压（PAH）的动物模型显示肾素血管紧张素系统上调。然而，尚无临床数据支持血管紧张素II抑制治疗PAH的疗效。在本综述中，我们将更新与原发性高血压相比PAH中RAS系统调节的相关知识，以寻求更好的PAH治疗方法。