Karchoud Jeanet F, Hoeboer Chris M, Karaban Irina, Mouthaan Joanne, Sijbrandij Marit, Olff Miranda, van de Schoot Rens, van Zuiden Mirjam
Amsterdam UMC, University of Amsterdam, Psychiatry, Amsterdam Public Health, Amsterdam, The Netherlands.
Leiden University, Department of Clinical Psychology, Leiden, The Netherlands.
Npj Ment Health Res. 2025 Aug 7;4(1):35. doi: 10.1038/s44184-025-00153-7.
Investigating long-term posttraumatic stress disorder (PTSD) course and its predictors may guide prevention and early intervention strategies following trauma exposure, potentially reducing the long-lasting impact of trauma. N = 155 emergency-admitted adults with (suspected) serious injury were repeatedly assessed until one-year post-trauma and completed a 12-15 year follow-up including a clinical PTSD interview. Adverse one-year PTSD trajectories; more exposure to additional potentially traumatic events and recent life stressors; and early post-trauma predictors (younger age, greater perceived impact of prior potentially traumatic events, higher heart rate) were significantly associated with higher PTSD symptom severity 12-15 years post-trauma. This study showed high consistency between one-year PTSD and its early post-trauma predictors with long-term PTSD outcomes. Early post-trauma predictors had predictive value up to 12-15 years. This suggests that early risk identification of one-year PTSD and subsequent effective early interventions also hold long-term beneficial effects for PTSD outcome.
调查创伤后应激障碍（PTSD）的长期病程及其预测因素，可能会为创伤暴露后的预防和早期干预策略提供指导，从而有可能减轻创伤的长期影响。155名因（疑似）重伤而急诊入院的成年人接受了多次评估，直至创伤后一年，并完成了一项12至15年的随访，其中包括一次PTSD临床访谈。不良的一年期PTSD轨迹；更多地暴露于其他潜在创伤事件和近期生活压力源；以及创伤后早期预测因素（年龄较小、先前潜在创伤事件的感知影响较大、心率较高）与创伤后12至15年时较高的PTSD症状严重程度显著相关。本研究表明，一年期PTSD及其创伤后早期预测因素与长期PTSD结果之间具有高度一致性。创伤后早期预测因素在长达12至15年的时间内都具有预测价值。这表明，对一年期PTSD进行早期风险识别以及随后进行有效的早期干预，对PTSD的结果也具有长期的有益影响。
