Pun Sunita, Ojha Neebha, Koirala Poonam
Department of Obstetrics and Gynecology, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.
J Nepal Health Res Counc. 2025 Jun 29;23(1):176-179. doi: 10.33314/jnhrc.v23i01.5621.
Several studies have investigated the relationships between female reproductive diseases and ABO blood groups. However, evidence regarding the potential association between ABO blood groups and adenomyosis remains limited. The aim of the study, thus, was to investigate the association between ABO blood groups and the risk of developing adenomyosis in Nepalese women.
A cross-sectional study was conducted at the department of obstetrics and gynecology, Tribhuvan University Teaching Hospital, Maharajgunj, from 2016 to 2017. Statistical analysis was done using Statistical Package for Social Sciences (SPSS, 29). Odd ratio with their corresponding 95% confidence intervals, and P-value were calculated and analyzed. A P-value equal or < 0.05 was considered statistically significant. Results: A total of 249 with recorded ABO groups were included in this study. Of these, 85 cases (34%) were histologically confirmed to have adenomyosis. The most frequent ABO blood group was B (43%), while the least frequent group was AB (6%). Women with blood group B had a significantly increased risk of developing adenomyosis, with an odds ratio of 2.3 (95% CI: 1.22-4.43, P value = 0.01). Conversely, blood group A was associated with a significantly reduced risk of adenomyosis, with an odds ratio of 0.41 (95% CI: 0.19-0.89, P value= 0.03). Conclusions: This study demonstrated that women with blood group B have a 2.3-fold higher risk of developing adenomyosis, whereas those with blood group A may have a protective effect. Multicenter studies with larger sample sizes and diverse demographics groups are needed to substantiate these findings.
Adenomyosis; ABO blood group; risk factors.
多项研究调查了女性生殖疾病与ABO血型之间的关系。然而，关于ABO血型与子宫腺肌病潜在关联的证据仍然有限。因此，本研究的目的是调查尼泊尔女性中ABO血型与患子宫腺肌病风险之间的关联。
2016年至2017年在加德满都马哈拉杰甘吉特里布万大学教学医院妇产科进行了一项横断面研究。使用社会科学统计软件包（SPSS，版本29）进行统计分析。计算并分析比值比及其相应的95%置信区间和P值。P值等于或<0.05被认为具有统计学意义。结果：本研究共纳入249例记录了ABO血型的患者。其中，85例（34%）经组织学证实患有子宫腺肌病。最常见的ABO血型是B型（43%），而最不常见的是AB型（6%）。B型血的女性患子宫腺肌病的风险显著增加，比值比为2.3（95%CI：1.22 - 4.43，P值 = 0.01）。相反，A型血与子宫腺肌病风险显著降低相关，比值比为0.41（95%CI：0.19 - 0.89，P值 = 0.03）。结论：本研究表明，B型血的女性患子宫腺肌病的风险高2.3倍，而A型血的女性可能具有保护作用。需要进行更大样本量和不同人口统计学群体的多中心研究来证实这些发现。
子宫腺肌病；ABO血型；危险因素
