一例λ型四聚体本斯-琼斯蛋白血症。
A case of lambda type tetramer Bence-Jones proteinemia.
作者信息
Kozuru M, Benoki H, Sugimoto H, Sakai K, Ibayashi H
出版信息
Acta Haematol. 1977;57(6):359-65. doi: 10.1159/000207904.
A 50-year-old woman was found to have an extramedullary plasmacytoma of the thoracic vertebrae and a bone marrow plasmacytosis of 72%. In the serum of this myeloma patient, M-bow percipitin line was seen only with anti-lambda chain serum, but not with antisera against mu, alpha, gamma, delta, ipsilon and kappa chains. Gel filtration of the serum on the Sephadex G-200 column demonstrated the monoclonal lambda chain in the A-fraction along with transferrin and suggests a molecular weight of 88,000 and a tetrameric light chain. Bence-Jones protein has never been detected in the patient's urine.
一名50岁女性被发现患有胸椎髓外浆细胞瘤，骨髓浆细胞增多症达72%。在该骨髓瘤患者的血清中，仅在抗λ链血清中可见M带沉淀素线，而在抗μ、α、γ、δ、ε和κ链的抗血清中未见。血清在Sephadex G - 200柱上进行凝胶过滤，结果显示在A组分中与转铁蛋白一起存在单克隆λ链，其分子量为88,000，为四聚体轻链。该患者尿液中从未检测到本-周蛋白。
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