Perez Martinez Carlos, Palacios-Galicia Jose Luis, Vargas-Diaz Irma B, Munoz Alvaro, Cruz Yolanda
Doctorado en Ciencias Biológicas, Universidad Autónoma de Tlaxcala, Tlaxcala, Tlaxcala, Mexico.
Centro de Urologia Avanzada (CURA), Delicias, Chihuahua, Mexico.
Front Urol. 2024 Feb 19;4:1352701. doi: 10.3389/fruro.2024.1352701. eCollection 2024.
This study aimed to investigate the efficacy of six episodes of percutaneous tibial nerve stimulation (PTNS) treatment for overactive bladder (OAB) symptoms in men and women and to determine the duration of the effects over a 6-month period.
Women and men with OAB symptoms participated in the study, which was conducted in accordance with an approved ethical protocol (ISRCTN15733799). Patients underwent six 30-min PTNS sessions, twice per week. The symptoms of OAB were assessed using a voiding diary, the short form of the Overactive Bladder Symptom Score questionnaire (OAB-q SF), and the Patient Perception of Bladder Condition (PPBC), which were self-completed by patients before and after treatment (24 h and at 1, 3, and 6 months). The outcome data were compared for sex and time points using two-way ANOVA for repeated measures.
PTNS treatment significantly improved the OAB symptoms and quality of life in men and women. PTNS increased the voided volume ( < 0.05) and decreased the frequency of voiding, nocturia, and urgency at 24 h and up to 6 months ( < 0.001). The OABq-SF and PPBC scores were significantly decreased after PTNS ( < 0.001). Urgency was greater in men than in women. The duration of PTNS clinical success on frequency and the perception of improvement in quality of life were greater in women than in men.
The clinical effects of six sessions of PTNS strongly suggest its potential for shortening, from the standard 12 sessions, to effectively alleviate symptoms of OAB. This therapeutic procedure would reduce both the time and economic costs of OAB treatment.
本研究旨在调查六次经皮胫神经刺激（PTNS）治疗对男性和女性膀胱过度活动症（OAB）症状的疗效，并确定6个月内效果的持续时间。
有OAB症状的男性和女性参与了本研究，该研究按照批准的伦理方案（ISRCTN15733799）进行。患者每周接受两次，每次30分钟的PTNS治疗，共六次。使用排尿日记、膀胱过度活动症症状评分问卷简表（OAB-q SF）和患者膀胱状况感知（PPBC）对OAB症状进行评估，患者在治疗前和治疗后（24小时以及1、3和6个月）自行填写。使用重复测量的双向方差分析对性别和时间点的结果数据进行比较。
PTNS治疗显著改善了男性和女性的OAB症状及生活质量。PTNS增加了排尿量（<0.05），并在24小时至6个月内降低了排尿频率、夜尿次数和尿急程度（<0.001）。PTNS治疗后，OAB-q SF和PPBC评分显著降低（<0.001）。男性的尿急程度高于女性。PTNS在频率方面临床成功的持续时间以及生活质量改善的感知在女性中比男性更长。
六次PTNS治疗的临床效果强烈表明其有可能从标准的12次缩短疗程，以有效缓解OAB症状。这种治疗方法将减少OAB治疗的时间和经济成本。
