• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

2-{[(1,2)-1-羟基-1-苯基-丙-2-基](甲基)氨基}-(3-甲基-苯基)乙酰胺

2-{[(1,2)-1-Hy-droxy-1-phenyl-propan-2-yl](methyl)amino}--(3-methyl-phen-yl)acetamide.

作者信息

Bobonazarova Sarvinoz, Torambetov Batirbay, Burieva Dilnoza, Abdushukurov Anvar, Kadirova Shakhnoza, Okmanov Rasul Ya, Yusufov Mukhriddin

机构信息

National University of Uzbekistan named after Mirzo Ulugbek 4 University St Tashkent 100174 Uzbekistan.

Physical and Material Chemistry Division CSIR-National Chemical Laboratory,Pune 411008 India.

出版信息

IUCrdata. 2025 Jul 4;10(Pt 7):x250578. doi: 10.1107/S2414314625005784. eCollection 2025 Jul.

DOI:10.1107/S2414314625005784
PMID:40777614
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12326468/
Abstract

The title compound, CHNO (-TAP), was synthesized the reaction of 2-chloro--(-tol-yl)acetamide with pseudoephidrine. It crystallizes in the monoclinic crystal system with a non-centrosymmetric chiral space group 2 (No. 4). The asymmetric unit comprises a single mol-ecule. The dihedral angle between the phenyl rings is 89.20 (10)°. -TAP contains two chiral centers at the C7 and C8 positions, both with an absolute configuration of .

摘要

标题化合物CHNO（-TAP）是由2-氯-（-对甲苯基）乙酰胺与伪麻黄碱反应合成的。它以单斜晶系结晶，具有非中心对称的手性空间群P212121（编号4）。不对称单元包含一个单分子。苯环之间的二面角为89.20（10）°。-TAP在C7和C8位置含有两个手性中心，两者的绝对构型均为。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94b5/12326468/b007ecec7242/x-10-x250578-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94b5/12326468/925866af9128/x-10-x250578-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94b5/12326468/5db3186cc062/x-10-x250578-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94b5/12326468/b007ecec7242/x-10-x250578-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94b5/12326468/925866af9128/x-10-x250578-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94b5/12326468/5db3186cc062/x-10-x250578-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94b5/12326468/b007ecec7242/x-10-x250578-fig3.jpg

相似文献

1
2-{[(1,2)-1-Hy-droxy-1-phenyl-propan-2-yl](methyl)amino}--(3-methyl-phen-yl)acetamide.2-{[(1,2)-1-羟基-1-苯基-丙-2-基](甲基)氨基}-(3-甲基-苯基)乙酰胺
IUCrdata. 2025 Jul 4;10(Pt 7):x250578. doi: 10.1107/S2414314625005784. eCollection 2025 Jul.
2
2-({[(2)-1-Hy-droxy-1,1,3-tri-phenyl-propan-2-yl]imino}-meth-yl)-4,6-bis-(4-methyl-phen-yl)phenol.2 - ({[(2) - 1 - 羟基 - 1,1,3 - 三苯基丙 - 2 - 基]亚氨基}甲基) - 4,6 - 双(4 - 甲基苯基)苯酚
IUCrdata. 2020 Dec 4;5(Pt 12):x201576. doi: 10.1107/S241431462001576X. eCollection 2020 Dec.
3
Synthesis and structure of ()--(4-meth-oxy-phen-yl)-2-[4-(3-oxo-3-phenyl-prop-1-en-1-yl)phen-oxy]acetamide.（）-（4-甲氧基苯基）-2-[4-（3-氧代-3-苯基丙-1-烯-1-基）苯氧基]乙酰胺的合成与结构
Acta Crystallogr E Crystallogr Commun. 2021 Jan 29;77(Pt 2):184-189. doi: 10.1107/S2056989021000864. eCollection 2021 Feb 1.
4
Bis(4-hy-droxy-phen-yl) 1,4-phenyl-enebiscarbamate.双（4-羟基苯基）1,4-亚苯基双氨基甲酸酯
IUCrdata. 2022 Sep 27;7(Pt 9):x220919. doi: 10.1107/S2414314622009191. eCollection 2022 Sep.
5
The crystal structure of the zwitterionic co-crystal of 2,4-di-chloro-6-{[(3-hy-droxy-prop-yl)azaniumyl]-meth-yl}phenolate and 2,4-di-chloro-phenol.2,4-二氯-6-{[(3-羟基丙基)铵基]甲基}苯酚盐与2,4-二氯苯酚的两性离子共晶体的晶体结构。
Acta Crystallogr E Crystallogr Commun. 2019 Sep 10;75(Pt 10):1452-1455. doi: 10.1107/S2056989019012544. eCollection 2019 Oct 1.
6
Crystal structure and photoreactive behaviour of ,-diisoprop-yl(-phenyl-phen-yl)glyoxyl-amide.α,α-二异丙基（对苯基苯基）乙二酰苯胺的晶体结构与光反应行为
Acta Crystallogr E Crystallogr Commun. 2021 May 28;77(Pt 6):653-657. doi: 10.1107/S2056989021005387. eCollection 2021 Jun 1.
7
-(4-Meth-oxy-2-methyl-5-nitro-phen-yl)acetamide.-（4-甲氧基-2-甲基-5-硝基苯基）乙酰胺
IUCrdata. 2025 Jun 3;10(Pt 6):x250470. doi: 10.1107/S2414314625004705. eCollection 2025 Jun.
8
Crystal structures of three 4-methyl-piperidinium salts (one as three polymorphs) with tetrahalogenidoaurate(III), halide and (in one case) di-chloro-iodate(I) counter-anions.三种含四卤代金（III）酸盐、卤化物和（在一种情况下）二氯碘酸盐（I）抗衡阴离子的4-甲基哌啶鎓盐（其中一种有三种多晶型物）的晶体结构
Acta Crystallogr E Crystallogr Commun. 2025 Jun 12;81(Pt 7):600-612. doi: 10.1107/S2056989025004918. eCollection 2025 Jul 1.
9
(1,2)-2-[()-2,2,2-Tri-fluoro-1-hy-droxy-eth-yl]-1-tetra-lol.(1,2)-2-[()-2,2,2-三氟-1-羟基-乙基]-1-四醇。 （注：原文中“tetra-lol”表述不太准确规范，可能影响准确理解，或许是“tetrol”之类的错误表述）
IUCrdata. 2023 Mar 15;8(Pt 3):x230217. doi: 10.1107/S2414314623002171. eCollection 2023 Mar.
10
2-{()-[(2-Hy-droxy-1-phenyl-eth-yl)imino]-meth-yl}-4-[()-(4-methyl-phen-yl)diazen-yl]phenol.2-{()-[(2-羟基-1-苯基-乙基)亚氨基]-甲基}-4-[()-(4-甲基-苯基)重氮基]-苯酚。
IUCrdata. 2025 Jul 8;10(Pt 7):x250599. doi: 10.1107/S2414314625005991. eCollection 2025 Jul.

本文引用的文献

1
Comparison of silver and molybdenum microfocus X-ray sources for single-crystal structure determination.用于单晶结构测定的银和钼微焦点X射线源的比较。
J Appl Crystallogr. 2015 Jan 30;48(Pt 1):3-10. doi: 10.1107/S1600576714022985. eCollection 2015 Feb 1.
2
Use of intensity quotients and differences in absolute structure refinement.强度商数的使用及绝对结构精修中的差异
Acta Crystallogr B Struct Sci Cryst Eng Mater. 2013 Jun;69(Pt 3):249-59. doi: 10.1107/S2052519213010014. Epub 2013 May 17.
3
Synthesis and biological activity of novel barbituric and thiobarbituric acid derivatives against non-alcoholic fatty liver disease.
新型巴比妥酸和硫代巴比妥酸衍生物的合成及对非酒精性脂肪性肝病的生物活性。
Eur J Med Chem. 2011 Jun;46(6):2003-10. doi: 10.1016/j.ejmech.2011.02.033. Epub 2011 Feb 22.