Al-Fraihat Ali A, Malek Abdullah I, Pelletier Audrey, Endam Leandra, Desrosiers Martin, Hamadi Iyad
Department of Otolaryngology - Head and Neck Surgery, Dubai Health - MBRU, Dubai, ARE.
Research Center, University of Montreal Hospital Center (CRCHUM), Montreal, CAN.
Cureus. 2025 Jul 8;17(7):e87500. doi: 10.7759/cureus.87500. eCollection 2025 Jul.
Objective Chronic rhinosinusitis with nasal polyposis (CRSwNP) is prevalent worldwide, but regional variations in disease endotypes have been described. The Gulf region is unique in genetic background and environmental conditions, potentially influencing disease characteristics. This study aimed to compare phenotypic traits and serum biomarkers associated with type 2 disease between CRSwNP patients in the Gulf and Canada. Study design A retrospective observational study was conducted in a tertiary center in Dubai, comparing newly diagnosed CRSwNP patients from the United Arab Emirates (UAE), representative of the UAE, with two Canadian cohorts: severe chronic rhinosinusitis (CRS) patients, (Genetics of Chronic Rhinosinusitis 1 (GCRS1)) and CRSwNP patients (Genetics of Chronic Rhinosinusitis 2 (GCRS2)). Methods Serum eosinophilia, white blood cell (WBC), and immunoglobulin E (IgE) levels were analyzed to identify potential differences or similarities between the populations. Results Serum eosinophil counts and the percentage of subjects with high serum eosinophilia values (≥300 cells/µL) were similar across the UAE and Canadian groups. However, total serum IgE levels were higher in the UAE cohort, while reported allergy rates were significantly lower compared to the Canadian groups. Type 2 comorbidities were more frequently reported in the Canadian cohorts, potentially reflecting differences in diagnostic practices or patient reporting. Conclusion Despite environmental and population differences, the immunological profile of CRSwNP disease in the Gulf region closely mirrors that in North America, suggesting that management strategies developed and used in Western countries are applicable in the Gulf. Eosinophil screening in CRSwNP patients remains valuable to detect elevated levels, potentially indicative of vasculitis.
目的 伴鼻息肉的慢性鼻-鼻窦炎（CRSwNP）在全球范围内普遍存在，但已有研究描述了疾病内型的区域差异。海湾地区在遗传背景和环境条件方面具有独特性，可能会影响疾病特征。本研究旨在比较海湾地区和加拿大CRSwNP患者中与2型疾病相关的表型特征和血清生物标志物。研究设计 在迪拜的一家三级中心进行了一项回顾性观察研究，将来自阿拉伯联合酋长国（阿联酋）的新诊断CRSwNP患者（代表阿联酋）与两个加拿大队列进行比较：重度慢性鼻-鼻窦炎（CRS）患者（慢性鼻-鼻窦炎遗传学1（GCRS1））和CRSwNP患者（慢性鼻-鼻窦炎遗传学2（GCRS2））。方法 分析血清嗜酸性粒细胞、白细胞（WBC）和免疫球蛋白E（IgE）水平，以确定不同人群之间的潜在差异或相似性。结果 阿联酋和加拿大队列的血清嗜酸性粒细胞计数以及血清嗜酸性粒细胞值高（≥300个细胞/μL）的受试者百分比相似。然而，阿联酋队列的血清总IgE水平较高，而报告的过敏率与加拿大队列相比显著较低。2型合并症在加拿大队列中报告得更频繁，这可能反映了诊断实践或患者报告方面的差异。结论 尽管存在环境和人群差异，但海湾地区CRSwNP疾病的免疫特征与北美地区非常相似，这表明西方国家制定和使用的管理策略适用于海湾地区。对CRSwNP患者进行嗜酸性粒细胞筛查对于检测升高的水平仍然很有价值，这可能提示血管炎。
