Zhang Jiyan
The first department of gynecology, Cangzhou central hospital, Hebei, China.
Afr Health Sci. 2024 Sep;24(3):180-187. doi: 10.4314/ahs.v24i3.22.
To explore the correlation between abdominal fat and the occurrence risk of endometrial cancer (EC) in patients with polycystic ovary syndrome (PCOS).
The clinical information of 120 PCOS patients receiving treatment in our hospital from March 2019 to April 2022 were included in this study. Patients were divided into two groups, endometrial cancer (EC, n=35) and normal group (NM, n=85). Statistical analysis included t-test, c2-test, and Pearson's correlation coefficient. We analysed the data using logistic regression. The predictive accuracy and discriminative ability of the prediction model were assessed by the area under the receiver operating characteristic (ROC) curve (AUC) and calibration curves.
The incidence rate of EC in women with PCOS is 10.91% (12/110). Significant differences were found in waist circumference, hypertension, diabetes, hyperlipidemia, body mass index (BMI), waist-hip ratio (WHR), insulin resistance index (HOMA-IR), visceral fat area (VFA) oestrogen receptor, progesterone receptor, human epidermal growth factor receptor-2 (HER2), estradiol (E2), and luteinizing hormone (LH) between the two groups (P<0.05). No statistical difference was found in age, hip circumference, menopause, use of intrauterine device, progesterone (P) and follicle-stimulating hormone (FSH) between the groups (P>0.05). Multivariate logistic regression analysis showed that BMI, HOMA-IR, VFA and HER2 were independent influencing factors of EC in PCOS patients (P<0.05). The AUC of BMI, HOMA-IR, VFA, HER2 were 0.878 (95%CI: 0.8100.946), 0.831 (95%CI: 0.7510.911), 0.816 (95%CI: 0.704~0.929) and 0.737 (95%CI: 0.634,0.840), respectively. The model had more diagnostic effectiveness (AUC=0.973).
In PCOS disease, high-level BMI, HOMA-IR, VFA, and positive HER2 show an increased risk in the incidence of EC. These findings suggest that BMI, HOMA-IR, VFA, and HER2 are potential markers for Risk assessment of EC.HER2: Human epidermal growth factor receptor-2, E2: estradiol, P: progesterone, LH: Luteinizing hormone, FSH: Follicle-stimulating hormone.
探讨多囊卵巢综合征（PCOS）患者腹部脂肪与子宫内膜癌（EC）发生风险之间的相关性。
纳入2019年3月至2022年4月在我院接受治疗的120例PCOS患者的临床资料。将患者分为两组，子宫内膜癌组（EC，n = 35）和正常组（NM，n = 85）。统计分析包括t检验、c2检验和Pearson相关系数。采用逻辑回归分析数据。通过受试者操作特征（ROC）曲线下面积（AUC）和校准曲线评估预测模型的预测准确性和判别能力。
PCOS女性中EC的发病率为10.91%（12/110）。两组在腰围、高血压、糖尿病、高脂血症、体重指数（BMI）、腰臀比（WHR）、胰岛素抵抗指数（HOMA-IR）、内脏脂肪面积（VFA）、雌激素受体、孕激素受体、人表皮生长因子受体2（HER2）、雌二醇（E2）和黄体生成素（LH）方面存在显著差异（P<0.05）。两组在年龄、臀围、绝经、宫内节育器使用、孕激素（P）和卵泡刺激素（FSH）方面无统计学差异（P>0.05）。多因素逻辑回归分析显示，BMI、HOMA-IR、VFA和HER2是PCOS患者发生EC的独立影响因素（P<0.05）。BMI、HOMA-IR、VFA、HER2的AUC分别为0.878（95%CI：0.8100.946）、0.831（95%CI：0.7510.911）、0.816（95%CI：0.704~0.929）和0.737（95%CI：0.634，0.840）。该模型具有更高的诊断效能（AUC = 0.973）。
在PCOS疾病中，高水平的BMI、HOMA-IR、VFA和HER2阳性表明EC发病风险增加。这些发现提示BMI、HOMA-IR、VFA和HER2是EC风险评估的潜在标志物。HER2：人表皮生长因子受体2，E2：雌二醇，P：孕激素，LH：黄体生成素，FSH：卵泡刺激素。
