Jahren Silje Ekroll, Obrist Dominik, Haenggi Matthias, Burkhard Fiona, Clavica Francesco
ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland.
Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Front Urol. 2023 Oct 13;3:1258649. doi: 10.3389/fruro.2023.1258649. eCollection 2023.
To explore the feasibility of using pressure-volume (PV) catheters for cystometry. These catheters are well-established in cardiovascular research for simultaneous pressure and volume measurements in the left ventricle.
Urinary bladders with urethras were collected from domestic pigs for ex-vivo testing. Using a pump, bladders were filled up to 500ml at five different filling rates (15, 20, 25, 30, 35ml/min), and the resulting pressures and volumes were measured using a PV catheter. The bladder were compressed externally in three different areas (central, apex and outlet) to assess the PV catheter's ability to detect local changes in bladder volume.
Bladder pressure remained below 10cmH2O for all bladder filling rates. Volume measurements were compared with the volumes instilled by the pump (ground truth), proving high reproducibility and accuracy of the PV catheter measurements up to 400ml. Using the different sensing units of the PV catheter, local changes in bladder volumes could be identified and quantified.
The main advantage of PV catheters, compared to existing technology used in urology (e.g. conventional urodynamic testing), is the possibility to i) simultaneously measure bladder pressure and volumes and ii) identify local changes in bladder volume (e.g. caused by non-voiding contractions). Both could be useful in the clinical setting to improve the diagnosis and treatment of the Lower Urinary Tract Dysfunction (e.g. overactive/underactive bladder).
探讨使用压力 - 容积（PV）导管进行膀胱测压的可行性。这些导管在心血管研究中已被广泛应用于左心室压力和容积的同步测量。
收集带有尿道的家猪膀胱用于体外测试。使用泵以五种不同的充盈速率（15、20、25、30、35毫升/分钟）将膀胱充盈至500毫升，并使用PV导管测量由此产生的压力和容积。在膀胱的三个不同区域（中央、顶部和出口）进行外部挤压，以评估PV导管检测膀胱容积局部变化的能力。
在所有膀胱充盈速率下，膀胱压力均保持在10厘米水柱以下。将容积测量值与泵注入的容积（真实值）进行比较，结果表明PV导管测量在高达400毫升时具有高重现性和准确性。使用PV导管的不同传感单元，可以识别和量化膀胱容积的局部变化。
与泌尿外科现有技术（如传统尿动力学检测）相比，PV导管的主要优势在于：i）能够同时测量膀胱压力和容积；ii）能够识别膀胱容积的局部变化（如由非排尿性收缩引起的变化）。这两者在临床环境中对于改善下尿路功能障碍（如膀胱过度活动症/膀胱活动不足）的诊断和治疗可能都很有用。
