de Smith Adam J
Center for Genetic Epidemiology, University of Southern California Keck School of Medicine, Los Angeles, California.
Blood Cancer Discov. 2025 Sep 3;6(5):400-402. doi: 10.1158/2643-3230.BCD-25-0221.
In this issue of Blood Cancer Discovery, Newman and colleagues investigated the impact of genetic ancestry on molecular subtypes, genomic alterations, and survival outcomes in a diverse cohort of patients with T-cell acute lymphoblastic leukemia. They demonstrated that the prognostic utility of genomic alterations varied by ancestry, in particular, with NOTCH1 mutations having no prognostic utility in patients of predominantly African ancestry, and their findings highlight the importance of considering genetic ancestry in the risk stratification of patients with T-ALL. See related article by Newman et al., p. 412.
在本期《血癌发现》中，纽曼及其同事调查了遗传血统对不同队列的T细胞急性淋巴细胞白血病患者的分子亚型、基因组改变和生存结果的影响。他们证明，基因组改变的预后效用因血统而异，特别是NOTCH1突变在主要为非洲血统的患者中没有预后效用，他们的研究结果突出了在T-ALL患者风险分层中考虑遗传血统的重要性。见纽曼等人的相关文章，第412页。
