Lu Louisa, Manche Edward
From the Byers Eye Institute, Stanford University, Stanford, California.
J Cataract Refract Surg. 2025 Oct 1;51(10):889-894. doi: 10.1097/j.jcrs.0000000000001703.
To compare the visual outcomes of eyes treated with ocular wavefront-guided (OWFG) LASIK vs topography-guided (TG) LASIK.
Byers Eye Institute at Stanford University, Stanford, California.
Prospective, randomized, contralateral eye-controlled trial. Treatments were randomized according to ocular dominance.
This study treated patients with myopia or compound myopic astigmatism with OWFG-LASIK (planned using the iDesign Advanced WaveScan Studio System aberrometer) in 1 eye and TG-LASIK (planned using the Contoura Vision and WaveLight Topolyzer Vario) in the fellow eye from January 2023 to April 2024. Postoperative evaluation was performed at 1, 3, 6, and 12 months postoperatively and consisted of visual acuity, manifest refraction, 5% and 25% low-contrast visual acuity, and higher-order aberrations (HOAs) (coma, trefoil, and spherical aberration).
100 eyes of 50 patients with myopia or compound myopic astigmatism were enrolled in the study and underwent successful treatments. 96 eyes of 48 patients completed 12 months of follow-up. At postoperative month 12, there were no statistically significant differences between the OWFG-LASIK and TG-LASIK groups for spherical equivalent ( P > .05); HOAs, including coma, trefoil, and spherical aberrations ( P > .05); proportion of eyes that had ≥20/20 uncorrected distance visual acuity (UDVA) (100% in the OWFG-LASIK group vs 98% in the TG-LASIK group); or proportion of eyes that had improved 5% and 25% low-contrast visual acuity. Eyes randomized to OWFG-LASIK had a significant greater percentage of eyes achieving UDVA of 20/12.5 compared with TG-LASIK ( P = .003).
OWFG LASIK and TG LASIK achieve similar refractive results with excellent clinical outcomes and excellent predictability in both groups.
比较眼波前引导（OWFG）准分子原位角膜磨镶术（LASIK）与地形引导（TG）LASIK治疗眼睛的视觉效果。
加利福尼亚州斯坦福大学拜尔斯眼科研究所。
前瞻性、随机、对侧眼对照试验。治疗根据眼优势进行随机分配。
本研究于2023年1月至2024年4月，对一只眼睛采用OWFG-LASIK（使用iDesign高级波前像差仪系统进行规划），对另一只眼睛采用TG-LASIK（使用Contoura Vision和WaveLight Topolyzer Vario进行规划）治疗近视或复合性近视散光患者。术后1、3、6和12个月进行评估，包括视力、显验光、5%和25%低对比度视力以及高阶像差（HOAs）（彗差、三叶草像差和球差）。
50例近视或复合性近视散光患者的100只眼睛纳入研究并成功接受治疗。48例患者的96只眼睛完成了12个月的随访。术后12个月时，OWFG-LASIK组和TG-LASIK组在等效球镜度（P>.05）、包括彗差、三叶草像差和球差的高阶像差（P>.05）、未矫正远视力（UDVA）≥20/20的眼睛比例（OWFG-LASIK组为100%，TG-LASIK组为98%）或5%和25%低对比度视力改善的眼睛比例方面，均无统计学显著差异。与TG-LASIK相比，随机分配至OWFG-LASIK的眼睛中，达到20/12.5 UDVA的眼睛比例显著更高（P=.003）。
OWFG LASIK和TG LASIK在两组中均取得了相似的屈光结果，具有良好的临床效果和出色的可预测性。
