Mihalceanu Silvia, Toberer Ferdinand
Universitäts-Hautklinik Heidelberg, Ruprecht-Karls Universität Heidelberg, Im Neuenheimer Feld 440, 69120, Heidelberg, Deutschland.
Dermatologie (Heidelb). 2025 Aug 8. doi: 10.1007/s00105-025-05547-4.
Poikilodermatous mycosis fungoides is a rare variant of mycosis fungoides (MF), characterized by a distinctive triad of epidermal atrophy, reticulated coalescing erythematous papules or plaques, and telangiectasia. Histologically, a band-like infiltrate of epidermotropic atypical lymphocytes can be observed. Diagnostic differentiation from other poikilodermatous dermatoses is challenging due to overlapping clinical and histopathological features. We present the case of a 66-year-old woman with slowly progressive cutaneous lesions on the trunk over a period of 6 years, whose definitive diagnosis was only established through serial skin biopsies and immunohistochemical analyses. This case underscores the diagnostic challenges and highlights the importance of close clinicopathological correlation.
色素沉着性蕈样肉芽肿是蕈样肉芽肿（MF）的一种罕见变体，其特征为独特的三联征，即表皮萎缩、网状融合性红斑丘疹或斑块以及毛细血管扩张。组织学上，可观察到亲表皮性非典型淋巴细胞的带状浸润。由于临床和组织病理学特征重叠，与其他色素沉着性皮炎进行诊断鉴别具有挑战性。我们报告了一例66岁女性患者，其躯干皮肤病变在6年时间里缓慢进展，最终诊断仅通过系列皮肤活检和免疫组化分析得以确立。该病例强调了诊断挑战，并突出了密切的临床病理相关性的重要性。
