Sun Yingying, Liu Chunyan, Wang Huaquan, Shao Zonghong
Clin Lab. 2025 Aug 1;71(8). doi: 10.7754/Clin.Lab.2025.250156.
Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT) is a rare aggressive vari-ant of non-Hodgkin lymphoma (NHL). It is also clinically uncommon for NHL to primarily manifest as immune thrombocytopenia (ITP).
We report a rare case of PCDLBCL-LT, which was misdiagnosed as primary refractory ITP. He achieved a complete remission of ITP by cyclophosphamide. Five months later, the patient developed recurrent erythematous plaques that disseminated to his entire body, accompanied by extracutaneous lesions.
Skin biopsy indicated PCDLBCL-LT. After one cycle of CHOP regimen, the patient's condition improved.
When encountering refractory ITP, it is important to identify potential underlying causes.
原发性皮肤弥漫性大B细胞淋巴瘤，腿部型（PCDLBCL-LT）是一种罕见的侵袭性非霍奇金淋巴瘤（NHL）变体。NHL主要表现为免疫性血小板减少症（ITP）在临床上也不常见。
我们报告了一例罕见的PCDLBCL-LT病例，该病例最初被误诊为原发性难治性ITP。他通过环磷酰胺治疗使ITP完全缓解。五个月后，患者出现复发性红斑斑块并扩散至全身，伴有皮肤外病变。
皮肤活检显示为PCDLBCL-LT。经过一个周期的CHOP方案治疗后，患者病情有所改善。
遇到难治性ITP时，识别潜在的潜在病因很重要。
