糖皮质激素对井上-梅尔尼克病毒生长的抑制作用。
Inhibitory effect of glucocorticoid hormones on the growth of Inoue-Melnick virus.
作者信息
Inoue Y K, Nishibe Y, Melnick J L, Seidel E, Wang S S
出版信息
J Clin Microbiol. 1985 Oct;22(4):664-5. doi: 10.1128/jcm.22.4.664-665.1985.
Abstract
Glucocorticoid hormones inhibited the early stage of propagation of Inoue-Melnick virus in a dose-dependent manner in human diploid cell cultures. Prednisolone and hydrocortisone achieved complete inhibition of replication of the three Inoue-Melnick virus serotypes at concentrations of 0.2 X 10(-4) and 10(-5) M, respectively; strong inhibition was found even at 10(-5) and 10(-6) M, respectively. The steroid hormones did not show a direct effect on the virus.
摘要
糖皮质激素在人二倍体细胞培养物中以剂量依赖的方式抑制井上-梅尔尼克病毒增殖的早期阶段。泼尼松龙和氢化可的松分别在浓度为0.2×10⁻⁴和10⁻⁵ M时实现了对三种井上-梅尔尼克病毒血清型复制的完全抑制；即使分别在10⁻⁵和10⁻⁶ M时也发现了强烈抑制作用。这些甾体激素对病毒未表现出直接作用。
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