Graetz Ilana, Hernandez Samuel, Hu Xin, Krukowski Rebecca A, Anderson Janeane N, Waters Teresa M, Stepanski Edward, Vidal Gregory A, Schwartzberg Lee S
Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Medical College of Georgia, Augusta, GA, USA.
Breast. 2025 Aug 5;83:104552. doi: 10.1016/j.breast.2025.104552.
Adjuvant endocrine therapy (AET) improves survival in hormone receptor-positive breast cancer, yet adherence is often lower among individuals with limited health literacy. This post hoc analysis of the THRIVE trial examined whether health literacy modified the effectiveness of two remote monitoring interventions (App-only and App + Feedback) versus enhanced usual care (EUC) on 12-month AET adherence (≥80 % of prescribed doses via connected pillbox). Among participants with lower health literacy, adherence was higher with App + Feedback than EUC (80.0 % vs. 42.1 %, p = 0.03), with no significant differences among those with higher health literacy. Tailored digital interventions may support adherence among patients with limited health literacy. TRIAL: ClinicalTrial.gov identifier NCT03592771.
辅助内分泌治疗（AET）可提高激素受体阳性乳腺癌患者的生存率，但健康素养有限的个体对其依从性往往较低。这项对THRIVE试验的事后分析研究了健康素养是否会改变两种远程监测干预措施（仅应用程序和应用程序+反馈）与强化常规护理（EUC）相比对12个月AET依从性（通过联网药盒服用规定剂量的≥80%）的有效性。在健康素养较低的参与者中，应用程序+反馈组的依从性高于EUC组（80.0%对42.1%，p = 0.03），而健康素养较高的参与者之间无显著差异。量身定制的数字干预措施可能有助于提高健康素养有限患者的依从性。试验：ClinicalTrial.gov标识符NCT03592771。
