剧情转折：TET2克隆拯救大脑。
Plot twist: TET2 clones save the brain.
作者信息
Telpoukhovskaia Maria A, Trowbridge Jennifer J
机构信息
The Jackson Laboratory, Bar Harbor, ME, USA.
The Jackson Laboratory, Bar Harbor, ME, USA.
出版信息
Cell Stem Cell. 2025 Aug 7;32(8):1187-1189. doi: 10.1016/j.stem.2025.07.001.
PMID:40780187
Abstract
While clonal hematopoiesis (CH) is associated with protection from Alzheimer's disease (AD), a limited understanding of the mechanisms by which this occurs has been a barrier to therapeutic intervention. In a new study, Matatall et al. discover protective mechanisms by which TET2-mutant, but not DNMT3A-mutant, CH impacts dementia pathology and cognition.
摘要
虽然克隆性造血（CH）与预防阿尔茨海默病（AD）相关，但对其发生机制的有限了解一直是治疗干预的障碍。在一项新研究中，马塔塔尔等人发现了TET2突变而非DNMT3A突变的CH影响痴呆病理和认知的保护机制。
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