Sartani A, Papatheodossiou N, Parrinello L, Mandelli V
J Clin Pharmacol. 1985 Nov-Dec;25(8):596-600. doi: 10.1002/j.1552-4604.1985.tb02883.x.
The relative potency of intravenous indoprofen and intramuscular pentazocine in postoperative pain was evaluated. Indoprofen was administered in 200- and 400-mg single doses and pentazocine was given in 15- and 30-mg doses. Pain was assessed at different time intervals, and additional medication consumption was recorded, as well as side effects and overall evaluations. An analysis of peak pain intensity difference (PID) has shown a significant dose-effect relationship for both drugs and a potency ratio of 1:7 between indoprofen and pentazocine (mg to mg). Based on the frequency of patients requiring remedication and those reporting total pain relief in at least one instance, the potency ratio of indoprofen:pentazocine was 1:13 and 1:10, respectively. The mean peak PID of the pooled data for both doses of each drug was significantly greater for indoprofen. Intravenous indoprofen 400 mg was ranked the most effective overall.
评估了静脉注射吲哚美辛和肌肉注射喷他佐辛对术后疼痛的相对效价。吲哚美辛以200毫克和400毫克单剂量给药，喷他佐辛以15毫克和30毫克剂量给药。在不同时间间隔评估疼痛，并记录额外药物消耗、副作用及总体评价。对峰值疼痛强度差异（PID）的分析显示，两种药物均存在显著的剂量效应关系，吲哚美辛与喷他佐辛的效价比为1:7（毫克对毫克）。基于需要补救治疗的患者频率以及至少有一次报告完全缓解疼痛的患者频率，吲哚美辛与喷他佐辛的效价比分别为1:13和1:10。每种药物两种剂量的汇总数据的平均峰值PID，吲哚美辛显著更高。静脉注射400毫克吲哚美辛总体上被评为最有效。
