Qiu Dan, Li Lixia, Yu Xiaoqing, Xiao Zhenhua, Chen Keqian, Wang Zongbao, Wang Shuzhi
Institute of Pharmacy and Pharmacology, School of Pharmaceutical Sciences, Hengyang Medical School, University of South China, Hengyang, 421001, China; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, 421001, China.
Department of Clinical Pharmacy, Xiangtan Central Hospital (The Affiliated Hospital of Hunan University), Xiangtan, 411100, China.
Eur J Pharmacol. 2025 Oct 15;1005:178050. doi: 10.1016/j.ejphar.2025.178050. Epub 2025 Aug 6.
Circadian rhythms are 24-h oscillating variations in physiology and behavior generated by the circadian clock, enabling an individual's circadian cycle to synchronize with the external light-dark cycle. The circadian clock precisely regulates multiple aspects of the innate immune system, including immune cells and diverse immune parameters. The oscillations of innate immune cells and their effector molecules typically determine the extent of the inflammatory responses. During the onset of cardiovascular diseases, many innate immune cells accumulate at the lesion sites. Their continuously augmented recruitment and effector function typically drive the progression of pathological processes and often coincide with cardiovascular events during their peak activities. It is essential to comprehensively understand the influence of the circadian clock on the trafficking and function of innate immune cells, as this influence exerts profound impacts on the immune and inflammatory responses to specific cardiovascular diseases, such as atherosclerosis and myocardial infarction. Proposing innate immunotherapy targeting the circadian clock is anticipated to offer valuable insights for the prevention and management strategies of cardiovascular diseases.
昼夜节律是由生物钟产生的生理和行为的24小时振荡变化，使个体的昼夜节律周期能够与外部明暗周期同步。生物钟精确调节固有免疫系统的多个方面，包括免疫细胞和各种免疫参数。固有免疫细胞及其效应分子的振荡通常决定炎症反应的程度。在心血管疾病发作期间，许多固有免疫细胞在病变部位积聚。它们不断增加的募集和效应功能通常驱动病理过程的进展，并且在其活动高峰期常常与心血管事件同时发生。全面了解生物钟对固有免疫细胞运输和功能的影响至关重要，因为这种影响对特定心血管疾病（如动脉粥样硬化和心肌梗死）的免疫和炎症反应产生深远影响。提出针对生物钟的固有免疫疗法有望为心血管疾病的预防和管理策略提供有价值的见解。
