Hansen-Abeck Inga, Hillemans Mina, Abeck Finn, Schneider Stefan W, Booken Nina
Department of Dermatology and Venereology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
J Dtsch Dermatol Ges. 2025 Sep;23(9):1061-1069. doi: 10.1111/ddg.15824. Epub 2025 Aug 8.
Xanthoma disseminatum is a rare disease from the spectrum of non-Langerhans cell histiocytoses, which can be categorized into three types and is sometimes associated with systemic involvement. Due to the its rarity, there are no standardized treatment guidelines for this disease, making treatment in everyday clinical practice more difficult. The aim of this study was therefore to summarize the therapeutic experience of the last 22 years by conducting a systematic literature review and thus generate an overview of the various treatment options. A systematic literature review on the topic of xanthoma disseminatum and applied treatment strategies was conducted in the PubMed/MEDLINE database for the period from 26 June 2002 to 26 June 2024. The literature search resulted in 38 publications, 19 of which were included in the review. The therapeutic approaches of the studies analyzed can be divided into immunosuppressive, cytostatic-based, lipid-lowering, surgical, UV radiation, and laser-based therapeutic approaches. Therapy with cladribine was reported most frequently. The current data is mainly based on case reports and case series, which are presented and summarized in this review. It can therefore be used as a basis for treatment decisions.
播散性黄瘤是一种非朗格汉斯细胞组织细胞增生症谱系中的罕见疾病，可分为三种类型，有时与全身受累有关。由于其罕见性，该病尚无标准化的治疗指南，这使得日常临床实践中的治疗更加困难。因此，本研究的目的是通过进行系统的文献综述来总结过去22年的治疗经验，从而概述各种治疗选择。在PubMed/MEDLINE数据库中对2002年6月26日至2024年6月26日期间关于播散性黄瘤主题及应用治疗策略的文献进行了系统综述。文献检索得到38篇出版物，其中19篇纳入综述。所分析研究的治疗方法可分为免疫抑制、基于细胞毒性、降脂、手术、紫外线辐射和基于激光的治疗方法。关于克拉屈滨治疗的报道最为频繁。当前数据主要基于病例报告和病例系列，本综述对其进行了呈现和总结。因此，它可作为治疗决策的依据。
