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囊袋收缩的有限元模型及其对人工晶状体位置的影响。

Finite element model of capsular bag contraction and its effect on IOL position.

作者信息

Feng Liying, Weeber Henk, Rozema Jos

机构信息

Johnson & Johnson Surgical Vision, 9728 NX, Groningen, the Netherlands; Visual Optics Lab Antwerp (VOLANTIS), Faculty of Medicine and Health Sciences, University of Antwerp, 2000, Antwerp, Belgium.

Johnson & Johnson Surgical Vision, 9728 NX, Groningen, the Netherlands.

出版信息

Exp Eye Res. 2025 Oct;259:110564. doi: 10.1016/j.exer.2025.110564. Epub 2025 Aug 7.

Abstract

In cataract surgery, once the cataractous lens is removed, an intraocular lens (IOL) is inserted into the capsular bag. After surgery, some patients may experience fibrosis that can lead to capsule contraction. Typically, only part(s) of the capsular bag exhibit(s) fibrosis and subsequent contraction of the capsule. The capsular contraction exerts a mechanical effect on the IOL that affects its position that can be quantified using modelling techniques. This study presents a simplified finite element model consisting of the capsular bag, intraocular lens, and zonular forces to simulate capsular fibrosis following cataract surgery. The model was used to simulate contractions of up to 20 % in various regions of the capsular bag and evaluate the biomechanical stability of the IOL, including lens decentration, tilt, and rotation. Capsular bag contractions of 20 % resulted in IOL decentrations between 0.34 mm and 0.51 mm, and tilts between 0.48° and 3.5°. The direction of the decentration and tilt was related to the location of the region being contracted. IOL rotations ranged between 1.6° and 7.8°, which could affect the effectiveness of the astigmatic correction in Toric IOLs. Capsular contraction affecting both the anterior and posterior capsule caused the largest decentration, while contraction in areas distant from the haptic resulted in the most significant amounts of IOL tilt. The IOL centration, tilt, and orientation depend considerably on the regions being contracted and the amount of contraction. This result may be used to improve the mechanical stability of IOLs in response to capsular contraction.

摘要

在白内障手术中,一旦摘除白内障晶状体,就会将人工晶状体(IOL)植入囊袋内。手术后,一些患者可能会出现纤维化,进而导致囊袋收缩。通常,只有部分囊袋会出现纤维化以及随后的囊袋收缩。囊袋收缩会对人工晶状体产生机械作用,影响其位置,这可以通过建模技术进行量化。本研究提出了一个简化的有限元模型,该模型由囊袋、人工晶状体和悬韧带力组成,用于模拟白内障手术后的囊膜纤维化。该模型用于模拟囊袋各个区域高达20%的收缩情况,并评估人工晶状体的生物力学稳定性,包括晶状体偏心、倾斜和旋转。囊袋收缩20%会导致人工晶状体偏心在0.34毫米至0.51毫米之间,倾斜在0.48°至3.5°之间。偏心和倾斜的方向与收缩区域的位置有关。人工晶状体旋转在1.6°至7.8°之间,这可能会影响散光人工晶状体的散光矫正效果。影响前囊和后囊的囊袋收缩导致最大的偏心,而远离襻的区域收缩则导致人工晶状体倾斜量最大。人工晶状体的中心定位、倾斜和方向在很大程度上取决于收缩区域和收缩量。这一结果可用于提高人工晶状体在应对囊袋收缩时的机械稳定性。

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